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219457 Cdk Inhibitor, p35 - CAS 471270-60-7 - Calbiochem

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Synonyme: 2-(3-Hydroxypropylamino)-6-(o-hydroxybenzylamino)-9-isopropylpurine

Primary Target: CDK1, CDK2
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      471270-60-7C₁₈H₂₄N₆O₂
      Description
      Overview

      This product has been discontinued.



      An analog of Olomoucine (Cat. No. 495620) that acts as a potent inhibitor of Cdk1 (IC50 = 100 nM) and Cdk2 (IC50 = 80 nM). Also displays anti-proliferative and pro-apoptotic effects. The correlation between inhibition of Cdk1/Cdk2 and inhibition of cell proliferation suggests that the anti-proliferative effects are due, in part, to Cdk inhibition.
      Catalogue Number219457
      Brand Family Calbiochem®
      Synonyms2-(3-Hydroxypropylamino)-6-(o-hydroxybenzylamino)-9-isopropylpurine
      References
      ReferencesVermeulen, K., et al. 2002. Leukemia 16, 299.
      Product Information
      CAS number471270-60-7
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₈H₂₄N₆O₂
      Chemical formulaC₁₈H₂₄N₆O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCDK1, CDK2
      Primary Target IC<sub>50</sub>100 nM, 80 nM, against Cdk1 and Cdk2, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      219457 0

      Documentation

      Cdk Inhibitor, p35 - CAS 471270-60-7 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Cdk Inhibitor, p35 - CAS 471270-60-7 - Calbiochem Analysenzertifikate

      TitelChargennummer
      219457

      Literatur

      Übersicht
      Vermeulen, K., et al. 2002. Leukemia 16, 299.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonyms2-(3-Hydroxypropylamino)-6-(o-hydroxybenzylamino)-9-isopropylpurine
      DescriptionAn analog of Olomoucine (Cat. No. 495620) that acts as a potent inhibitor of Cdk1 (IC50 = 100 nM) and Cdk2 (IC50 = 80 nM). Also displays anti-proliferative and pro-apoptotic effects.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number471270-60-7
      Chemical formulaC₁₈H₂₄N₆O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesVermeulen, K., et al. 2002. Leukemia 16, 299.