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217708 Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem

Cdc42/Rac1 GTPase Inhibitor, ML141, CAS 71203-35-5, is a cell-permeable, allosteric, potent, selective, reversible, non-competitive inhibitor of Cdc42 GTPases.

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Synonyme: CID2950007, (±)-4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl))-benzenesulfonamide, (±)-4-(4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl)-benzenesulfonamide, MLS00693334, CDC42 GTPase Inhibitor II, CDC42 Inhibitor II, Rac1 Inhibitor V, Rac1 GTPase Inhibitor II

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217708
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
71203-35-5C₂₂H₂₁N₃O₃S

Preis & Verfügbarkeit

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217708-25MG
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      Description
      OverviewA cell-permeable, allosteric, trisubstituted dihydropyrazolyl compound that acts as a potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPases (IC50 = 0.2, 2.6 and 5.4 µM against nucleotide depleted Cdc42-wt, Cdc42-wt and Cdc42 activated mutant, respectively) with excellent selectivity over Rho family GTPases (IC50 > 100 µM for Ras-wt, Ras activated mutant, Rab7-wt, Rab2a-wt, Rac1-wt and Rac1 activated mutant). Shown to efficiently block Cdc42 association with GTPγS and PAK-PBD, and decrease GTP-Cdc42 (> 95%) and GTP-Rac1 (≥40%) contents in EGF-stimulated 3T3 cells, and inhibit Bradykinin (Cat. No. 05-23-0500)-induced filopodia formation in 3T3 cells at 10 µM.
      Catalogue Number217708
      Brand Family Calbiochem®
      SynonymsCID2950007, (±)-4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl))-benzenesulfonamide, (±)-4-(4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl)-benzenesulfonamide, MLS00693334, CDC42 GTPase Inhibitor II, CDC42 Inhibitor II, Rac1 Inhibitor V, Rac1 GTPase Inhibitor II
      References
      ReferencesHong, L., et al. 2012. J. Biol. Chem. in press.
      Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2010 Feb 27. (http://www.ncbi.nlm.nih.gov/books/NBK51965/)
      Product Information
      CAS number71203-35-5
      FormYellow-white solid
      Hill FormulaC₂₂H₂₁N₃O₃S
      Chemical formulaC₂₂H₂₁N₃O₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCdc42/Rac1 GTPase Inhibitor, ML141, CAS 71203-35-5, is a cell-permeable, allosteric, potent, selective, reversible, non-competitive inhibitor of Cdc42 GTPases.
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      217708-25MG 04055977202366

      Documentation

      Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem Analysenzertifikate

      TitelChargennummer
      217708

      Literatur

      Übersicht
      Hong, L., et al. 2012. J. Biol. Chem. in press.
      Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2010 Feb 27. (http://www.ncbi.nlm.nih.gov/books/NBK51965/)
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-February-2013 JSW
      SynonymsCID2950007, (±)-4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl))-benzenesulfonamide, (±)-4-(4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl)-benzenesulfonamide, MLS00693334, CDC42 GTPase Inhibitor II, CDC42 Inhibitor II, Rac1 Inhibitor V, Rac1 GTPase Inhibitor II
      DescriptionA cell-permeable, allosteric, trisubstituted dihydropyrazolyl compound that acts as a potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPases (IC50 = 0.2, 2.6 and 5.4 µM against nucleotide depleted Cdc42-wt, Cdc42-wt and Cdc42 activated mutant, respectively) with excellent selectivity over Rho family GTPases (IC50 > 100 µM for Ras-wt, Ras activated mutant, Rab7-wt, Rab2a-wt, Rac1-wt and Rac1 activated mutant). Shown to efficiently block Cdc42 association with GTPγS and PAK-PBD, and decrease GTP-Cdc42 (> 95%) and GTP-Rac1 (≥40%) contents in EGF-stimulated 3T3 cells, and inhibit Bradykinin (Cat. No. 05-23-0500)-induced filopodia formation in 3T3 cells at 10 µM.
      FormYellow-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number71203-35-5
      Chemical formulaC₂₂H₂₁N₃O₃S
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHong, L., et al. 2012. J. Biol. Chem. in press.
      Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2010 Feb 27. (http://www.ncbi.nlm.nih.gov/books/NBK51965/)