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219479 Cdc2-Like Kinase Inhibitor, TG003 - CAS 300801-52-9 - Calbiochem

The Cdc2-Like Kinase Inhibitor, TG003, also referenced under CAS 300801-52-9, controls the biological activity of Cdc2-Like. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

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Synonyme: (Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one, Clk Inhibitor, TG003

Primary Target: mClk4, mClk1, mClk2, mClk3
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      300801-52-9C₁₃H₁₅NO₂S
      Description
      OverviewA cell-permeable dihydrobenzothiazolo compound that acts as a potent, specific, reversible, and ATP-competitive inhibitor of Clk-family of kinases (Ki = 10 nM for mClk1/Sty; IC50 = 15 nM, 20 nM, 200 nM, and > 10 µM for mClk4, mClk1, mClk2, and mClk3, respectively). Does not affect the activities of SRPK1, SRPK2, PKA, or PKC up to 1 µM. Shown to alter the regulation of alternative splicing mediated by phosphorylation of Ser/Arg-rich (SR) proteins both in vitro and in vivo. Suppresses early Xenopus developmental abnormality induced by excess levels of Clk-activity.
      Catalogue Number219479
      Brand Family Calbiochem®
      Synonyms(Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one, Clk Inhibitor, TG003
      References
      ReferencesMuraki, M., et al. 2004. J. Biol. Chem. 279, 24246.
      Product Information
      CAS number300801-52-9
      ATP CompetitiveY
      FormOff-white solid
      Hill FormulaC₁₃H₁₅NO₂S
      Chemical formulaC₁₃H₁₅NO₂S
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetmClk4, mClk1, mClk2, mClk3
      Primary Target IC<sub>50</sub>15 nM, 20 nM, 200 nM, >10 µM for mClk4, mClk1, mClk2, and mClk3, respectively
      Primary Target K<sub>i</sub>10 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      219479 0

      Documentation

      Cdc2-Like Kinase Inhibitor, TG003 - CAS 300801-52-9 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Cdc2-Like Kinase Inhibitor, TG003 - CAS 300801-52-9 - Calbiochem Analysenzertifikate

      TitelChargennummer
      219479

      Literatur

      Übersicht
      Muraki, M., et al. 2004. J. Biol. Chem. 279, 24246.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-October-2007 JSW
      Synonyms(Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one, Clk Inhibitor, TG003
      DescriptionA cell-permeable, potent, specific, reversible, and ATP-competitive inhibitor of the Clk family of kinases (Ki = 10 nM for mClk1/Sty; IC50 = 15 nM for mClk4, 20 nM for mClk1, and 200 nM for mClk2). However, it inhibits mClk3 only at higher concentrations (IC50 > 10 µM). Does not affect the activities of SRPK1, SRPK2, PKA, or PKC at concentrations up to 1 µM. Shown to alter the regulation of alternative splicing that is mediated by phosphorylation of Ser/Arg-rich (SR) proteins both in vitro and in vivo. Suppresses early Xenopus developmental abnormalities induced by excess levels of Clk activity.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number300801-52-9
      Chemical formulaC₁₃H₁₅NO₂S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml) or Methanol (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMuraki, M., et al. 2004. J. Biol. Chem. 279, 24246.