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218713 Casein Kinase II Inhibitor IV - CAS 863598-09-8 - Calbiochem

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Synonyme: 3-(3-(2-(3,4,5-Trimethoxy-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)propionitrile, Casein Kinase II Inhibitor IV, Keratinocyte Differentiation Inducer

218713
  
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      863598-09-8C₂₄H₂₃N₅O₃
      Description
      Overview

      This product has been discontinued.



      A cell-permeable pyrrolo-pyrimidone compound that acts as a potent, ATP-competitive inhibitor of casein kinase II (IC50 = 9 nM) and an effective inducer of normal human keratinocytes (NHEK) differentiation (EC50 = 100 nM). In addition to CKII, it is also shown to interact, directly or indirectly, with cellular TANK-binding Kinase 1 (TBK1) and NIMA-related kinase 9 (NEK9).
      Catalogue Number218713
      Brand Family Calbiochem®
      Synonyms3-(3-(2-(3,4,5-Trimethoxy-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)propionitrile, Casein Kinase II Inhibitor IV, Keratinocyte Differentiation Inducer
      References
      ReferencesHong, J., et al. 2007. ACS Chem. Biol. 2, 171.
      Product Information
      CAS number863598-09-8
      FormBeige solid
      Hill FormulaC₂₄H₂₃N₅O₃
      Chemical formulaC₂₄H₂₃N₅O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥90% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months as supplied.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      218713 0

      Documentation

      Casein Kinase II Inhibitor IV - CAS 863598-09-8 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Casein Kinase II Inhibitor IV - CAS 863598-09-8 - Calbiochem Analysenzertifikate

      TitelChargennummer
      218713

      Literatur

      Übersicht
      Hong, J., et al. 2007. ACS Chem. Biol. 2, 171.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-January-2012 JSW
      Synonyms3-(3-(2-(3,4,5-Trimethoxy-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)propionitrile, Casein Kinase II Inhibitor IV, Keratinocyte Differentiation Inducer
      DescriptionA cell-permeable pyrrolo-pyrimidone compound that acts as a potent, ATP-competitive inhibitor of casein kinase II (IC50 = 9 nM) and an effective inducer of normal human keratinocytes (NHEK) differentiation (EC50 = 100 nM). In addition to CKII, it is also shown to interact, directly or indirectly, with cellular TANK-binding Kinase 1 (TBK1) and NIMA-related kinase 9 (NEK9).
      FormBeige solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number863598-09-8
      Chemical formulaC₂₄H₂₃N₅O₃
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (15 mg/ml) or Ethanol (3 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months as supplied.
      Toxicity Standard Handling
      ReferencesHong, J., et al. 2007. ACS Chem. Biol. 2, 171.