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211875 Captopril - CAS 62571-86-2 - Calbiochem

Captopril - CAS 62571-86-2 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: [2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline, SQ-14225

Primary Target: ACE
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      62571-86-2C₉H₁₅NO₃S
      Description
      Overview

      This product has been discontinued.



      An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC50= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM). Inhibits angiogenesis and slows the growth of experimental tumors in rats. Reported to inhibit apoptosis in human lung epithelial cells (IC50 = ~ 320 nM).
      Catalogue Number211875
      Brand Family Calbiochem®
      Synonyms[2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline, SQ-14225
      References
      ReferencesUhal, B.D., et al. 1998. Am. J. Physiol. 275, L1013.
      Volpert, O.V., et al. 1996. J. Clin. Invest. 98, 671.
      Voors, A.A., et al. 1995. J. Cardiovasc. Risk 2, 413.
      Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
      Kostis, J. 1988. Am. Heart J. 116, 1591.
      Product Information
      CAS number62571-86-2
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₉H₁₅NO₃S
      Chemical formulaC₉H₁₅NO₃S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetACE
      Primary Target IC<sub>50</sub>23-35 nM against angiotensin-converting enzyme (ACE); 11 µM against LTA4 hydrolase; ~ 320 nM inhibiting apoptosis in human lung epithelial cells
      Purity≥98% by titration
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUY0550000
      Safety Information
      R PhraseR: 63-43

      Possible risk of harm to the unborn child.
      May cause sensitization by skin contact.
      S PhraseS: 22-36

      Do not breathe dust.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      211875 0

      Documentation

      Captopril - CAS 62571-86-2 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Captopril - CAS 62571-86-2 - Calbiochem Analysenzertifikate

      TitelChargennummer
      211875

      Literatur

      Übersicht
      Uhal, B.D., et al. 1998. Am. J. Physiol. 275, L1013.
      Volpert, O.V., et al. 1996. J. Clin. Invest. 98, 671.
      Voors, A.A., et al. 1995. J. Cardiovasc. Risk 2, 413.
      Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
      Kostis, J. 1988. Am. Heart J. 116, 1591.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2008 RFH
      Synonyms[2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline, SQ-14225
      DescriptionAn antihypertensive agent. Reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM). Also a competitive inhibitor of angiotensin-converting enzyme (ACE). Inhibits angiogenesis and slows the growth of experimental tumors in rats.
      FormWhite to off-white solid
      CAS number62571-86-2
      RTECSUY0550000
      Chemical formulaC₉H₁₅NO₃S
      Structure formulaStructure formula
      Purity≥98% by titration
      SolubilityH₂O (1 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 1774
      ReferencesUhal, B.D., et al. 1998. Am. J. Physiol. 275, L1013.
      Volpert, O.V., et al. 1996. J. Clin. Invest. 98, 671.
      Voors, A.A., et al. 1995. J. Cardiovasc. Risk 2, 413.
      Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
      Kostis, J. 1988. Am. Heart J. 116, 1591.