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208734 Calmodulin Binding Domain - CAS 115044-69-4 - Calbiochem

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Synonyme: Calmodulin antagonist, CaM kinase II 290-309

Primary Target: Calmodulin dependent Protein Kinase-2
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      115044-69-4C₁₀₃H₁₈₅N₃₁O₂₄S
      Description
      Overview

      This product has been discontinued.



      Potent calmodulin antagonist. Inhibits activation of calmodulin-dependent protein kinase II (IC50 = 52 nM). Interacts with the catalytic core of CaM kinase II as a pseudosubstrate.
      Catalogue Number208734
      Brand Family Calbiochem®
      SynonymsCalmodulin antagonist, CaM kinase II 290-309
      References
      ReferencesJames, P., et al. 1995. Trends Biochem. Sci. 20, 38.
      Mukherji, S., and Soderling, T.R. 1995. J. Biol. Chem. 270, 14062.
      Yazawa, M., et al. 1992. Biochemistry 31, 3171.
      Payne, M.E., et al. 1988. J. Biol. Chem. 263, 7190.
      Product Information
      CAS number115044-69-4
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₀₃H₁₈₅N₃₁O₂₄S
      Chemical formulaC₁₀₃H₁₈₅N₃₁O₂₄S
      Hygroscopic Hygroscopic
      ReversibleN
      Sold on the basis of peptide contentY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCalmodulin dependent Protein Kinase-2
      Primary Target IC<sub>50</sub>52 nM against calmodulin-dependent protein kinase II
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide ContentY
      Peptide SequenceH-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 year at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      208734 0

      Documentation

      Calmodulin Binding Domain - CAS 115044-69-4 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Calmodulin Binding Domain - CAS 115044-69-4 - Calbiochem Analysenzertifikate

      TitelChargennummer
      208734

      Literatur

      Übersicht
      James, P., et al. 1995. Trends Biochem. Sci. 20, 38.
      Mukherji, S., and Soderling, T.R. 1995. J. Biol. Chem. 270, 14062.
      Yazawa, M., et al. 1992. Biochemistry 31, 3171.
      Payne, M.E., et al. 1988. J. Biol. Chem. 263, 7190.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-May-2008 RFH
      SynonymsCalmodulin antagonist, CaM kinase II 290-309
      DescriptionA potent calmodulin antagonist that inhibits Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM) and Ca2+/calmodulin-dependent phosphodiesterase (IC50 = 1.1 nM).
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      CAS number115044-69-4
      Chemical formulaC₁₀₃H₁₈₅N₃₁O₂₄S
      Peptide SequenceH-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
      Purity≥95% by HPLC
      SolubilityH₂O
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 year at -20°C.
      Toxicity Standard Handling
      ReferencesJames, P., et al. 1995. Trends Biochem. Sci. 20, 38.
      Mukherji, S., and Soderling, T.R. 1995. J. Biol. Chem. 270, 14062.
      Yazawa, M., et al. 1992. Biochemistry 31, 3171.
      Payne, M.E., et al. 1988. J. Biol. Chem. 263, 7190.