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236011 COX-2 Inhibitor I - CAS 416901-58-1 - Calbiochem

The COX-2 Inhibitor I, also referenced under CAS 416901-58-1, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: LM-1685, Methyl [5-methylsulfonyl-1-(4-chlorobenzyl)-1H-2-indolyl]carboxylate

Primary Target: COX-2 from human monocytes
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      416901-58-1C₁₈H₁₆ClNO₄S
      Description
      OverviewA cell-permeable potent and selective inhibitor of COX-2 from human monocytes (IC50 = 650 nM) and in whole blood (IC50 = 4.3 µM). Displays only very weak activity against COX-1 from human platelets (IC50 > 10 µM) and in whole blood (IC50 > 100 µM).
      Catalogue Number236011
      Brand Family Calbiochem®
      SynonymsLM-1685, Methyl [5-methylsulfonyl-1-(4-chlorobenzyl)-1H-2-indolyl]carboxylate
      References
      ReferencesPalomer, A., et al. 2002. J. Med. Chem. 45, 1402.
      Product Information
      CAS number416901-58-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₈H₁₆ClNO₄S
      Chemical formulaC₁₈H₁₆ClNO₄S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCOX-2 from human monocytes
      Primary Target IC<sub>50</sub>650 nM against COX-2 from human monocytes; 4.3 µM against COX-2 in whole blood
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      236011 0

      Documentation

      COX-2 Inhibitor I - CAS 416901-58-1 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      COX-2 Inhibitor I - CAS 416901-58-1 - Calbiochem Analysenzertifikate

      TitelChargennummer
      236011

      Literatur

      Übersicht
      Palomer, A., et al. 2002. J. Med. Chem. 45, 1402.

      Broschüre

      Titel
      Alzheimer's Disease Brochure & Technical Guide
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-April-2011 RFH
      SynonymsLM-1685, Methyl [5-methylsulfonyl-1-(4-chlorobenzyl)-1H-2-indolyl]carboxylate
      DescriptionA cell-permeable potent, selective inhibitor of cyclooxygenase-2 (COX-2) (IC50 = 650 nM, human monocytes COX-2). Shown to specifically inhibit COX-2 in human whole blood (IC50 = 4.3 µM). Displays only weak inhibitory activity against COX-1 from human platelets (19% inhibition at 10 µM) and in whole blood (25% inhibition at 100 µM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number416901-58-1
      Chemical formulaC₁₈H₁₆ClNO₄S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml) or MeOH (1 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPalomer, A., et al. 2002. J. Med. Chem. 45, 1402.