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236007 COX-1 Inhibitor IV, TFAP - CAS 1011244-68-0 - Calbiochem

The COX-1 Inhibitor IV, TFAP, also referenced under CAS 1011244-68-0, controls the biological activity of COX-1. This small molecule/inhibitor is primarily used for Cell Signaling applications.

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Synonyme: N-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      1011244-68-0C₁₃H₁₀F₃N₃O
      Description
      OverviewA cell-permeable pyridinyl-benzamide compound that acts as a COX-1-selective inhibitor (IC50 = 0.80 and 210 µM against ovine COX-1 and COX-2, respectively) by targeting the enzyme's active site and displays analgesic properties in mice and rats in vivo (30 mg/kg, p.o.) without long-term cytotoxic effects (300 mg/kg in mice, daily, p.o. for 14 days). Unlike COX-2-inhibiting analgesics such as aspirin, TFAP is shown not to cause gastric damage in rats in vivo (300 mg/kg, p.o.).
      Catalogue Number236007
      Brand Family Calbiochem®
      SynonymsN-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide
      References
      ReferencesKakuta, H., et al. 2008. J. Med. Chem. 51, 2400.
      Product Information
      CAS number1011244-68-0
      FormOff-white solid
      Hill FormulaC₁₃H₁₀F₃N₃O
      Chemical formulaC₁₃H₁₀F₃N₃O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      236007 0

      Documentation

      COX-1 Inhibitor IV, TFAP - CAS 1011244-68-0 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      COX-1 Inhibitor IV, TFAP - CAS 1011244-68-0 - Calbiochem Analysenzertifikate

      TitelChargennummer
      236007

      Literatur

      Übersicht
      Kakuta, H., et al. 2008. J. Med. Chem. 51, 2400.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-April-2011 RFH
      SynonymsN-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide
      DescriptionA cell-permeable pyridinyl-benzamide compound that acts as a COX-1-selective inhibitor (IC50 = 0.80 and 210 µM against ovine COX-1 and COX-2, respectively) by targeting the enzyme's active site and displays analgesic properties in mice and rats in vivo (30 mg/kg, p.o.) without long-term cytotoxic effects (300 mg/kg in mice, daily p.o. for 14 days). Unlike COX-2-inhibiting analgesics such as aspirin, TFAP is shown not to cause gastric damage in rats in vivo (300 mg/kg, p.o.).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1011244-68-0
      Chemical formulaC₁₃H₁₀F₃N₃O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKakuta, H., et al. 2008. J. Med. Chem. 51, 2400.