220005 Sigma-AldrichCGP-37157 - CAS 75450-34-9 - Calbiochem
A cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+ exchanger (IC₅₀ = 360 nM).
More>> A cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+ exchanger (IC₅₀ = 360 nM). Less<<Synonyme: 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
Empfohlene Produkte
Übersicht
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Key Spec Table
CAS # | Empirical Formula |
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75450-34-9 | C₁₅H₁₁Cl₂NOS |
Product Information | |
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CAS number | 75450-34-9 |
ATP Competitive | N |
Form | White solid |
Hill Formula | C₁₅H₁₁Cl₂NOS |
Chemical formula | C₁₅H₁₁Cl₂NOS |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Primary Target | Mitochondrial Na+/Ca2+ exchanger |
Primary Target IC<sub>50</sub> | 360 nM against mitochondrial Na+/Ca2+ exchanger |
Purity | ≥98% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
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Packaged under inert gas | Packaged under inert gas |
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Bestellnummer | GTIN |
220005 | 0 |
Documentation
CGP-37157 - CAS 75450-34-9 - Calbiochem SDB
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CGP-37157 - CAS 75450-34-9 - Calbiochem Analysenzertifikate
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220005 |
Literatur
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Jornot, L., et al. 1999. J. Cell Sci. 112, 1013. Babcock, D.F., et al. 1997. J. Cell Biol. 136, 833. Baron. K.T., and Thayer, S.A. 1997. Eur. J. Pharmacol. 340, 295. Griffiths, E.J., et al. 1997. Cell Calcium 21, 321. White, R.J., and Reynolds, I.J. 1996, J. Neurosci. 16, 5688. Cox, D.A., et al. 1993. J. Cardivasc. Pharmacol. 21, 595. Cox, D.A., and Matlib, M.A. 1993. J. Biol. Chem. 268, 938. |