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506239 Bupropion Hydrochloride - CAS 31677-93-7 - Calbiochem

Bupropion is a non-selective inhibitor of dopamine and noradrenalin transporters. Also an antagonist for neuronal nicotinic acetylcholine receptors (nAChrs).

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Synonyme: Dopamine and noradrenalin Transporter Inibitor, Bupropion

Primary Target: DAT/NET
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506239
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Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
31677-93-7C₁₃H₁₈ClNO·HCl

Preis & Verfügbarkeit

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      Description
      OverviewA non-selective inhibitor of dopamine and noradrenalin transporters (Ki = 1.4, 2.8 and 45 µM for dopamine, noradrenalin, and serotonin transporters respectively). Also an antagonist for neuronal nicotinic acetylcholine receptors (nAChrs) (IC50 = 1.8 µM at α2β2 receptor). Clinically used as an antidepressant and smoking seceasion drug. Used in nicotinic addiction and depression studies.
      Catalogue Number506239
      Brand Family Calbiochem®
      SynonymsDopamine and noradrenalin Transporter Inibitor, Bupropion
      References
      ReferencesBudzynska, B. et al. 2011 Pharmacol. Rep. 63, 71.
      Dwoskin, P., et al. 2006. CNS Drug Rev. 12, 178.
      Soroko, F., et al. 1977. J. Pharm. Pharmacol. 29, 769.
      Product Information
      CAS number31677-93-7
      FormWhite solid
      Hill FormulaC₁₃H₁₈ClNO·HCl
      Chemical formulaC₁₃H₁₈ClNO·HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetDAT/NET
      Primary Target K<sub>i</sub>1.4 µ
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 46

      If swallowed, seek medical advice immediately and show this container or label.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5.06239.0001 04055977243185

      Documentation

      Bupropion Hydrochloride - CAS 31677-93-7 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Budzynska, B. et al. 2011 Pharmacol. Rep. 63, 71.
      Dwoskin, P., et al. 2006. CNS Drug Rev. 12, 178.
      Soroko, F., et al. 1977. J. Pharm. Pharmacol. 29, 769.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-September-2013 JSW
      SynonymsDopamine and noradrenalin Transporter Inibitor, Bupropion
      DescriptionA non-selective inhibitor of dopamine and noradrenalin transporters (Ki = 1.4, 2.8 and 45 µM for dopamine, noradrenalin, and serotonin transporters respectively). Also an antagonist for neuronal nicotinic acetylcholine receptors (nAChrs) (IC50 = 1.8 µM at α2β2 receptor). Clinically used as an antidepressant and smoking seceasion drug. Used in nicotinic addiction and depression studies.
      FormWhite solid
      CAS number31677-93-7
      Chemical formulaC₁₃H₁₈ClNO·HCl
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityH₂O
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesBudzynska, B. et al. 2011 Pharmacol. Rep. 63, 71.
      Dwoskin, P., et al. 2006. CNS Drug Rev. 12, 178.
      Soroko, F., et al. 1977. J. Pharm. Pharmacol. 29, 769.