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200485 Bestatin Methyl Ester - CAS 65322-89-6 - Calbiochem

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Synonyme: (-)-N-[(2S, 3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Methyl Ester

Primary Target: Neutral amino pepsidase
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      65322-89-6C₁₇H₂₆N₂O₄
      Description
      Overview

      This product has been discontinued.



      A cell-permeable derivative of Bestatin (Cat. No. 200484) that displays slightly stronger inhibition of neutral aminopeptidase than Bestatin but has much weaker activity against basic aminopeptidase. Also augments Fas- or TNF-α-induced apoptosis in solid tumor cell lines.
      Catalogue Number200485
      Brand Family Calbiochem®
      Synonyms(-)-N-[(2S, 3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Methyl Ester
      References
      ReferencesSekine, K., et al. 2001. Int. J. Cancer 94, 485.
      Product Information
      CAS number65322-89-6
      ATP CompetitiveN
      FormYellowish semi-solid
      Hill FormulaC₁₇H₂₆N₂O₄
      Chemical formulaC₁₇H₂₆N₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNeutral amino pepsidase
      Primary Target IC<sub>50</sub>31.6 nM against neutral amino pepsidase
      Purity≥97% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      200485 0

      Documentation

      Bestatin Methyl Ester - CAS 65322-89-6 - Calbiochem Analysenzertifikate

      TitelChargennummer
      200485

      Literatur

      Übersicht
      Sekine, K., et al. 2001. Int. J. Cancer 94, 485.

      Broschüre

      Titel
      Caspases and other Apoptosis Related Tools Brochure
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-March-2011 RFH
      Synonyms(-)-N-[(2S, 3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Methyl Ester
      DescriptionA cell-permeable derivative of Bestatin (Cat. No. 200484) that displays stronger inhibition of neutral aminopeptidase than Bestatin (IC50 = 31.6 nM). Exhibits weaker activity against basic aminopeptidase (IC50 = 400.1 nM). Also reported to augment Fas- (IC50 = 235.4 nM) or TNF-α-induced apoptosis in solid tumor cell lines.
      FormYellowish semi-solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number65322-89-6
      Chemical formulaC₁₇H₂₆N₂O₄
      Structure formulaStructure formula
      Purity≥97% by TLC
      SolubilityDMSO (100 mg/ml). Unstable in aqueous solution; dilute just prior to use.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesSekine, K., et al. 2001. Int. J. Cancer 94, 485.