505420 Sigma-AldrichBMP Inhibitor III, LDN-212854 - Calbiochem
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Primary Target:
ALK1/2/3
BMP Inhibitor III, LDN-212854 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: Abl Inhibitor V, LDN212854, Bone Morphogenetic Protein Inhibitor III, PDGFR Tyrosine Kinase Inhibitor XXIV, RIP2 Inhibitor I, RIPK2 Inhibitor I, 5-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Empfohlene Produkte
Übersicht
| Replacement Information |
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Key Spec Table
| Empirical Formula |
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| C₂₅H₂₂N₆ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 5.05420.0001 |
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Glasflasche | 5 mg |
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| Description | |
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| Overview | A cell-permeable pyrazolopyrimidinylquinoline that is superior to Dorsomorphin (Cat. Nos. 171260 and 171261) and DMH1 (Cat. No. 203646) as an ATP-site-targeting, ALK1/2 inhibitor (IC50 = 2.40 and 1.30 nM, respectively; [ATP] = 6 µM) with respect to both potency and selectivity over ALK3/4/5 (IC50 = 0.858, 2.133, and 9.276 µM, respectively). Also a potent RIPK2 inhibitor (IC50 = 6 nM) with reduced potency against ABL1/c-abl, PDGFR-β, ALK3, and PDGFR-α (IC50 = 40, 68, 85.8, and 650 nM, respectively) and little inhibitory activity toward a panel of more than 190 kinases. Effectively inhibits ALK2- and ALK3-mediated C2C12 osteogenic differentiation (IC50 = 10 and 40.5 nM, respectively) in vitro and prevents constitutively active ALK2 Q207D mutant-induced heterotopic ossification in mice (6 mg/kg/12 h via i.p.) in vivo. A good complement to the ALK4/5/7-selective A-83-01 (Cat. No. 616454). |
| Catalogue Number | 505420 |
| Brand Family | Calbiochem® |
| Synonyms | Abl Inhibitor V, LDN212854, Bone Morphogenetic Protein Inhibitor III, PDGFR Tyrosine Kinase Inhibitor XXIV, RIP2 Inhibitor I, RIPK2 Inhibitor I, 5-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline |
| References | |
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| References | Mohedas, A.H., et al. 2013. ACS Chem. Biol. 8, 1291. |
| Product Information | |
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| Form | Pale yellow solid |
| Hill Formula | C₂₅H₂₂N₆ |
| Chemical formula | C₂₅H₂₂N₆ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | ALK1/2/3 |
| Secondary target | RIP, Abl & PDGFR |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 5.05420.0001 | 04055977243840 |
Documentation
BMP Inhibitor III, LDN-212854 - Calbiochem SDB
| Titel |
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Literatur
| Übersicht |
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| Mohedas, A.H., et al. 2013. ACS Chem. Biol. 8, 1291. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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