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189484 Autocamtide-2 Related Inhibitory Peptide II - Calbiochem

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Synonyme: A3K/V10F-AIP, AIP-II, KKKLRRQEAFDAL

Primary Target: CAM Kinase-2
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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₇₁H₁₂₃N₂₃O₁₉
      Description
      Overview

      This product has been discontinued.



      An AIP (Cat. No. 189480) analog, in which Ala3 and Val10 are replaced with Lys and Phe respectively. Acts as a highly specific, potent inhibitor of calmodulin-dependent protein kinase II (CaMKII; IC50 = 4.1 nM). Displays ~10-fold greater potency than AIP. Inhibits PKC at higher concentrations (IC50 = 1 µM) and does not affect the activities of CaMK IV and PKA (IC50 > 100 µM).
      Catalogue Number189484
      Brand Family Calbiochem®
      SynonymsA3K/V10F-AIP, AIP-II, KKKLRRQEAFDAL
      References
      ReferencesIshida, A., et al. 1998. FEBS Lett. 427, 115.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₇₁H₁₂₃N₂₃O₁₉
      Chemical formulaC₇₁H₁₂₃N₂₃O₁₉
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCAM Kinase-2
      Primary Target IC<sub>50</sub>4.1 nM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      189484 0

      Documentation

      Autocamtide-2 Related Inhibitory Peptide II - Calbiochem Analysenzertifikate

      TitelChargennummer
      189484

      Literatur

      Übersicht
      Ishida, A., et al. 1998. FEBS Lett. 427, 115.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-April-2008 RFH
      SynonymsA3K/V10F-AIP, AIP-II, KKKLRRQEAFDAL
      DescriptionAn autocamtide-2 related inhibitory peptide (AIP) analog in which Ala3 and Val10 have been replaced with Lys and Phe, respectively. Acts as a highly specific, potent inhibitor of calmodulin-dependent protein kinase II (CaMKII) (IC50 = 4.1 nM). Displays ~10-fold greater potency than AIP (Cat. No. 189480). Inhibits PKC at higher concentrations (IC50 = 1 µM), but does not affect the activities of CaMKIV or PKA (IC50 >100 µM).
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₇₁H₁₂₃N₂₃O₁₉
      Peptide SequenceH-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesIshida, A., et al. 1998. FEBS Lett. 427, 115.