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189405 Aurora Kinase Inhibitor III - CAS 879127-16-9 - Calbiochem

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Synonyme: Cyclopropanecarboxylic acid-(3-(4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino)-phenyl)-amide, Aurora Kinase Inhibitor III

Primary Target: Aurora Kinase A
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      879127-16-9C₂₁H₁₈F₃N₅O
      Description
      Overview

      This product has been discontinued.



      A cell-permeable 2,4-dianilinopyrimidine compound that acts as an ATP-competitive, potent, but non-selective inhibitor of Aurora A (IC50 = 42 nM). At higher concentrations, also inhibits the activities of other kinases, such as Lck, Bmx, IGF-1R, and Syk (IC50 = 131, 386, 591, and 887 nM, respectively).
      Catalogue Number189405
      Brand Family Calbiochem®
      SynonymsCyclopropanecarboxylic acid-(3-(4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino)-phenyl)-amide, Aurora Kinase Inhibitor III
      References
      ReferencesZhang, Q., et al. 2006. J. Am. Chem. Soc. 128, 2182.
      Product Information
      CAS number879127-16-9
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₁H₁₈F₃N₅O
      Chemical formulaC₂₁H₁₈F₃N₅O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAurora Kinase A
      Primary Target IC<sub>50</sub>42 nM against Aurora A; 131, 386, 591, and 887 nM, against Lck, Bmx, IGF-1R, and Syk , respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      189405 0

      Documentation

      Aurora Kinase Inhibitor III - CAS 879127-16-9 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Aurora Kinase Inhibitor III - CAS 879127-16-9 - Calbiochem Analysenzertifikate

      TitelChargennummer
      189405

      Literatur

      Übersicht
      Zhang, Q., et al. 2006. J. Am. Chem. Soc. 128, 2182.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-December-2008 JSW
      SynonymsCyclopropanecarboxylic acid-(3-(4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino)-phenyl)-amide, Aurora Kinase Inhibitor III
      DescriptionA cell-permeable 2,4-dianilinopyrimidine compound that acts as an ATP-competitive, potent, but non-selective inhibitor of Aurora A (IC50 = 42 nM). At higher concentrations, also inhibits the activities of other kinases, such as Lck, Bmx, IGF-1R, and Syk (IC50 = 131, 386, 591, and 887 nM, respectively).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number879127-16-9
      Chemical formulaC₂₁H₁₈F₃N₅O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol (20 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesZhang, Q., et al. 2006. J. Am. Chem. Soc. 128, 2182.