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AB8123 Anti-phospho-Integrin β1 (Thr788/789) Antibody

This Anti-phospho-Integrin β1 (Thr788/789) Antibody is validated for use in WB for the detection of phospho-Integrin β1 (Thr788/789).

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Cell Structure Research Sub-Category: Integrins Gene Symbol: ITGB1, GPIIA, OTTHUMP00000063731, OTTHUMP00000046253, OTTHUMP00000063733, VLAB, OTTHUMP00000063732, MDF2, FNRB, CD29, MSK12 UniProt Number: P05556
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AB8123
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB8123
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-phospho-Integrin β1 (Thr788/789) Antibody
      References
      Product Information
      FormatSerum
      PresentationRaw Rabbit Serum with 0.1% Sodium Azide
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-phospho-Integrin β1 (Thr788/789) Antibody is validated for use in WB for the detection of phospho-Integrin β1 (Thr788/789).
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenC-terminal Peptide
      HostRabbit
      SpecificityIntegrin B1 phosphorylated on Thr788/789
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryIntegrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
      Gene Symbol
      • ITGB1
      • GPIIA
      • OTTHUMP00000063731
      • OTTHUMP00000046253
      • OTTHUMP00000063733
      • VLAB
      • OTTHUMP00000063732
      • MDF2
      • FNRB
      • CD29
      • MSK12
      Modifications
      • Phosphorylation
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P05556 # Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.


      SIZE: 798 amino acids; 88465 Da

      SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha- 5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Interacts with FLNA. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5 (By similarity). Interacts with FLNB and RANBP9. Isoform Beta-1D interacts with ACE2. Isoform Beta-1A interacts with the C-terminal region of FLNC. Interacts with HIV-1 Tat.

      SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Isoform beta-1B does not localize to focal adhesions. Highly enriched in stage I melanosomes.

      TISSUE SPECIFICITY: Isoform beta-1A is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform beta-1B is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbelical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform beta-1C and isoform beta-1C-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-C-2, rather than isoform beta-1C, is selectively expressed in primary T-cells. Isoform beta-1C is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1D is expressed specifically in striated muscle (skeletal and cardiac muscle).





      SIMILARITY: SwissProt: P05556 ## Belongs to the integrin beta chain family. & Contains 1 VWFA domain.
      Molecular Weight120kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at 4°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      AB8123 04053252673917

      Documentation

      Anti-phospho-Integrin β1 (Thr788/789) Antibody SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Anti-phospho-Integrin β1 (Thr788/789) Antibody Analysenzertifikate

      TitelChargennummer
      RABBIT ANTI-PHOSPHO INTEGRIN B1 (Thr788/789) -2749209 2749209
      RABBIT ANTI-PHOSPHO INTEGRIN B1 (Thr788/789) -2804187 2804187
      RABBIT ANTI-PHOSPHO INTEGRIN B1 (Thr788/789) POLYCLONAL ANTIBODY 2879606
      RABBIT ANTI-PHOSPHO INTEGRIN B1 (Thr788/789) POLYCLONAL ANTIBODY -2506066 2506066

      Literatur

      ÜbersichtPub Med ID
      Deletion of core fucosylation on alpha3beta1 integrin down-regulates its functions
      Zhao, Yanyang, et al
      J Biol Chem, 281:38343-50 (2006)  2005

      		17043354 17043354
      Epidermal Growth Factor Signaling for Matrix-Dependent Cell Proliferation and Differentiation in Primary Cultured Hepatocytes
      Kim, Sang-Heon and Akaike, Toshihiro
      Kim, Sang-Heon and Akaike, Toshihiro  2005

      		17198484 17198484

      Datenblatt

      Titel
      RABBIT ANTI-PHOSPHO INTEGRIN B1 (Thr788/789) POLYCLONAL ANTIBODY