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ABE1332 Anti-monomethyl Histone H2A (Gln104)

Anti-monomethyl Histone H2A (Gln104) Antibody, Cat. No. ABE1332, is a highly specific rabbit polyclonal antibody that targets histone H2A Gln104 monomethylation (Q104me) and has been tested by histone peptide array Dot Blot.

Anti-monomethyl Histone H2A (Gln104): SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Epigenetics & Nuclear Function Gene Symbol: HIST1H2AG, H2AFP, HIST1H2AI, H2AFC, HIST1H2AK, H2AFD, HIST1H2AL, H2AFI, HIST1H2AM, H2AFN UniProt Number: P0C0S8
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ABE1332
100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HDBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE1332
      DescriptionAnti-monomethyl Histone H2A (Gln104)
      Alternate Names
      • Histone H2A type 1, Gln104 monomethylated
      • H2A.1, Gln104 monomethylated
      • Histone H2A/p, Gln104 monomethylated
      • H2AQ104me, Gln104 monomethylated
      Background InformationHistone H2A type 1 (UniProt P0C0S8; also known as H2A.1, Histone H2A/p) is encoded by the HIST1H2AG (also known as H2AFP, HIST1H2AI, H2AFC, HIST1H2AK, H2AFD, HIST1H2AL, H2AFI, HIST1H2AM, H2AFN) gene (Gene ID 8969) in human. Histone H2A is one of four components of the core nucleosome structure. The nucleosome represents a unit of chromatin in which DNA is wrapped around a histone octamer. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones. Histones undergo a number of post-translational modifications in response to various stimuli that may induce changes in the structure of the nucleosome and hide or expose DNA sequences. Histone H2A, in particular, undergoes acetylation on lysine 5 by Tip60 enzyme, which may promote unfolding of chromatin and transcription. In addition, H2A is phosphorylated on serine 1 and serine 139 (H2A.X) residues, which mark mitosis and gene repression and DNA damage, respectively. Gene repression may also result from the sumoylation of H2A s lysine 126 residue. In addition, ubiquitination of the H2A lysine 119 residue may play a role in spermatogenesis. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-monomethyl Histone H2A (Gln104) Antibody, Cat. No. ABE1332, is a highly specific rabbit polyclonal antibody that targets histone H2A Gln104 monomethylation (Q104me) and has been tested by histone peptide array Dot Blot.
      Key Applications
      • Dot Blot
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human histone H2A target region sequence containing monomethylated Gln104 (Q104me).
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificitySpecificity of this polyclonal antibody was verified by dot blot analysis. This polyclonal antibody specifically detected peptide corresponding to histone H2A target region sequence with monomethylated Gln104 (Q104me), but not H2A peptides without Q104me modification, nor peptides derived from histone H1, H2A.Z, H2B, H3, H3.3, or H4 sequences.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HIST1H2AG
      • H2AFP
      • HIST1H2AI
      • H2AFC
      • HIST1H2AK
      • H2AFD
      • HIST1H2AL
      • H2AFI
      • HIST1H2AM
      • H2AFN
      Purification MethodAffinity purified.
      UniProt Number
      Molecular Weight13.96 kDa (Met1 removed) calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Dot Blot Analysis of histone peptide array.

      Dot Blot Analysis: A 1:200 dilution of this antibody detected 4-40 ng of histone H2A peptide containing monomethylated Gln104 (Q104me).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABE1332 04054839112300