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ABE555 Anti-WTAP Antibody

Anti-WTAP, Cat. No. ABE555, is a highly specific rabbit polyclonal antibody that targets WTAP and has been tested in Western Blotting.

Anti-WTAP Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Epigenetics & Nuclear Function Gene Symbol: WTAP, KIAA0105 UniProt Number: Q15007
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ABE555
100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, H, RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE555
      DescriptionAnti-WTAP Antibody
      Alternate Names
      • Pre-mRNA-splicing regulator WTAP
      • Female-lethal(2)D homolog
      • hFL(2)D
      • Wilms tumor 1-associating protein
      • WT1-associated protein
      Background InformationPre-mRNA-splicing regulator WTAP (UniProt Q15007; also known as Female-lethal (2)D homolog, hFL(2)D, Wilms tumor 1-associating protein, WT1-associated protein) is encoded by the WTAP (also known as KIAA0105) gene (Gene ID 9589) in human. WTAP is an ubiquitously expressed nuclear protein that is localized throughout the nucleoplasm and in speckles and partially co-localizes with splicing factors. A mouse homolog has also been reported that shares 96% sequence identity. WTAP regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. WTAP knockdown is shown to induce G2 accumulation, which is partially rescued by adenoviral overexpression of cyclin A2. WTAP-null mice exhibit proliferative failure with early embryonic death. WTAP is also reported to be an oncogenic protein in acute myeloid leukemia (AML) and its increased expression has been linked to chemoresistance in AML. Ref: Horiuchi, K., et al. (2006), Proc. Natl. Acad. Sci. USA 103, 17278-17283. Bansal, H., et al. (2014). Leukemia 28, 1171-1174.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-WTAP, Cat. No. ABE555, is a highly specific rabbit polyclonal antibody that targets WTAP and has been tested in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to an internal sequence within the N-terminal half of human WTAP.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis polyclonal antibody targets an internal sequence within the N-terminal half of human WTAP.
      Species Reactivity
      • Mouse
      • Human
      • Rat
      Species Reactivity NoteHuman, Mouse, Rat.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • WTAP
      • KIAA0105
      Purification MethodAffinity purified.
      UniProt Number
      Molecular Weight~52 observed. 44.24/17.80 kDa (isoform 1/2 calculated). Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in A431.

      Western Blotting Analysis: A 1:250 dilution of this antibody detected WTAP in 10 µg of A431 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABE555 04054839092046