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MAB7774 Anti-Urokinase Antibody, NT fragment, clone 10D.7.2

This Anti-Urokinase Antibody, N-terminus fragment, clone 10D.7.2 is validated for use in ELISA, WB for the detection of Urokinase.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Metabolism Research Sub-Category: Enzymes & Biochemistry Gene Symbol: PLAU, UPA, URK, u-PA, uPA, ATF, EC 3.4.21.73 [Contains: Urokinase-type plasminogen activator long chain A, Urokinase-type plasminogen activator short chain A, Urokinase-type plasminogen activator chain B]. UniProt Number: P00749
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MAB7774
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB7774
      ReplacesAB776
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Urokinase Antibody, NT fragment, clone 10D.7.2
      Alternate Names
      • uPA
      References
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin. Liquid in 0.02 M phosphate buffer containing 0.25 M NaCl2 and 0.1% NaN3.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Urokinase Antibody, N-terminus fragment, clone 10D.7.2 is validated for use in ELISA, WB for the detection of Urokinase.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 1:1000-1:3000

      ELISA

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenAmino Terminal Fragment of uPA
      EpitopeN-terminus fragment
      Clone10D.7.2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityUrokinase Plasminogen Acitivator is a serine protease (SERPIN) that converts plasminogen into the active protease plasmin. uPA is secreted from cells in as the inactive 52 kDa single chain precursor which is activated into the two chain form consisting of an alpha and beta chain.MAB7774 is specific for Human uPA, other species not tested.
      IsotypeIgG2a
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene's proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
      Gene Symbol
      • PLAU
      • UPA
      • URK
      • u-PA
      • uPA
      • ATF
      • EC 3.4.21.73 [Contains: Urokinase-type plasminogen activator long chain A
      • Urokinase-type plasminogen activator short chain A
      • Urokinase-type plasminogen activator chain B].
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P00749 # Specifically cleave the zymogen plasminogen to form the active enzyme plasmin.
      SIZE: 431 amino acids; 48525 Da
      SUBUNIT: Found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. Binds LRP1B; binding is followed by internalization and degradation. Interacts with MRC2. Interacts with PLAUR.
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: Expressed in the prostate gland and prostate cancers.
      PTM: Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.
      SIMILARITY: SwissProt: P00749 ## Belongs to the peptidase S1 family. & Contains 1 EGF-like domain. & Contains 1 kringle domain. & Contains 1 peptidase S1 domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C in undiluted aliquots for up to 6 months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MAB7774 04053252501609

      Documentation

      Anti-Urokinase Antibody, NT fragment, clone 10D.7.2 SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Anti-Urokinase Antibody, NT fragment, clone 10D.7.2 Analysenzertifikate

      TitelChargennummer
      Anti-Urokinase, NT fragment, clone 10D.7.2 - 3224572 3224572
      Anti-Urokinase, NT fragment, clone 10D.7.2 - 3445779 3445779
      Anti-Urokinase, NT fragment, clone 10D.7.2 - 3527823 3527823
      Anti-Urokinase, NT fragment, clone 10D.7.2 - 3817623 3817623
      Anti-Urokinase, NT fragment, clone 10D.7.2 - 4009745 4009745
      Anti-Urokinase, NT fragment, clone 10D.7.2 - 4010717 4010717
      Anti-Urokinase, NT fragment, clone 10D.7.2 - 4036223 4036223
      Anti-Urokinase, NT fragment, clone 10D.7.2 - 4148148 4148148
      Anti-Urokinase, NT fragment, clone 10D.7.2 -2794469 2794469
      Anti-Urokinase, NT fragment, clone 10D.7.2 -2821222 2821222
      Show more

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      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies