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AB5437S Anti-Tropomyosin Antibody, Smooth Muscle

Anti-Tropomyosin Antibody, Smooth Muscle detects level of Tropomyosin & has been published & validated for use in WB, IC, IH(P).

Anti-Tropomyosin Antibody, Smooth Muscle: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Metabolism Research Sub-Category: Muscle Physiology Gene Symbol: TPM1, CMH3, Tropomyosin-1, HTM-alpha, Alpha-tropomyosin, TMSA, C15orf13 UniProt Number: P09493
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AB5437S
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, ICC, IH(P)ShSerumPolyclonal Antibody
      Description
      Catalogue NumberAB5437S
      ReplacesAB5437
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Tropomyosin Antibody, Smooth Muscle
      References
      Product Information
      FormatSerum
      PresentationLiquid
      Quality LevelMQ100
      Applications
      ApplicationAnti-Tropomyosin Antibody, Smooth Muscle detects level of Tropomyosin & has been published & validated for use in WB, IC, IH(P).
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenSynthetic peptide corresponding to the 2a exon from the α gene of tropomyosin.
      HostSheep
      SpecificityRecognizes Tropomyosin, smooth muscle.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.
      Gene Symbol
      • TPM1
      • CMH3
      • Tropomyosin-1
      • HTM-alpha
      • Alpha-tropomyosin
      • TMSA
      • C15orf13
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P09493 # Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
      SIZE: 284 amino acids; 32709 Da
      SUBUNIT: Heterodimer of an alpha and a beta chain.
      TISSUE SPECIFICITY: Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients.
      DOMAIN: SwissProt: P09493 The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven- residues periodicity.
      DISEASE: SwissProt: P09493 # Defects in TPM1 are the cause of familial hypertrophic cardiomyopathy type 3 (CMH3) [MIM:115196]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy [MIM:192600] is a heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The prevalence of the disease in the general population is 0.2%. FHC is clinically heterogeneous, with inter- and intrafamilial variations ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
      SIMILARITY: Belongs to the tropomyosin family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      AB5437S 04053252733796

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      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies