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AB15624 Anti-Tbx1 Antibody

Anti-Tbx1 Antibody is a Rabbit Polyclonal Antibody for detection of Tbx1 also known as T-box 1 & has been validated in WB.

Anti-Tbx1 Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience, Neuronal & Glial Markers Gene Symbol: TBX1, CTHM, VCFS, brachyury, TGA, TBX1C, DGS, DORV, CAFS, DGCR UniProt Number: O43435
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AB15624
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB15624
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Tbx1 Antibody
      Alternate Names
      • T-box 1
      Background InformationThe T-box 1 protein appears to be necessary for the normal development of large arteries that carry blood out of the heart, muscles and bones of the face and neck, and glands such as the thymus and parathyroid. Although the T-box 1 protein acts as a transcription factor, it is not yet known which genes are regulated by the protein.
      References
      Product Information
      FormatPurified
      PresentationLiquid in PBS with 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Tbx1 Antibody is a Rabbit Polyclonal Antibody for detection of Tbx1 also known as T-box 1 & has been validated in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenSynthetic peptide from human Tbx1.
      HostRabbit
      SpecificityTbx1 (T-box 1).
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Other species have not been tested. The immunogen sequence has 76% homology with mouse.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
      Gene Symbol
      • TBX1
      • CTHM
      • VCFS
      • brachyury
      • TGA
      • TBX1C
      • DGS
      • DORV
      • CAFS
      • DGCR
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O43435 # Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries (By similarity).
      SIZE: 398 amino acids; 43133 Da
      SUBCELLULAR LOCATION: Nucleus (Potential).
      DISEASE: SwissProt: O43435 # Haploinsufficiency of the TBX1 gene is responsible for most of the physical malformations present in DiGeorge syndrome (DGS) and velocardiofacial syndrome (VCFS) [MIM:188400, 192430]. DGS is characterized by the association of several malformations: hypoplastic thymus and parathyroid glands, congenital conotruncal cardiopathy, and a subtle but characteristic facial dysmorphology. VCFS is marked by the association of congenital conotruncal heart defects, cleft palate or velar insufficiency, facial dysmorpholgy and learning difficulties. It is now accepted that these two syndromes represent two forms of clinical expression of the same entity manifesting at different stages of life. & Defects in TBX1 are a cause of DiGeorge syndrome (DGS) [MIM:188400]. & Defects in TBX1 are a cause of velocardiofacial syndrome (VCFS) [MIM:192430]. & Defects in TBX1 are a cause of conotruncal heart malformations (CTHM) [MIM:217095]. CTHM consist of cardiac outflow tract defects, such as tetralogy of Fallot, pulmonary atresia, double-outlet right ventricle, truncus arteriosus communis, and aortic arch anomalies.
      SIMILARITY: SwissProt: O43435 ## Contains 1 T-box DNA-binding domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -20°C from date of shipment
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      AB15624 04053252585814

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      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies