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96-Well Plate
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48-602MAG
Buffer Detection Kit for Magnetic Beads
1 Kit
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Tumor necrosis factor receptor superfamily member 1A (TNF-receptor 1 or CD120a) is a receptor for TNFSF2/TNF-alpha. TNF receptor mediates apoptosis and contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Binding of TNF to the extracellular domain of TNF receptor leads to homotrimerization. Defects in TNF receptor cause tumor necrosis factor receptor-associated periodic syndrome (TRAPS), a hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia.
References
Product Information
Format
Purified
Presentation
IgG fraction purified from tissue culture supernatant by protein-A affinity chromatography. Liquid in PBS pH 7.4 containing 0.09% sodium azide.
Applications
Application
Detect TNF Receptor using this Anti-TNF Receptor Antibody, extracellular, clone H398 validated for use in ELISA, FC, IP, RIA & WB.
Key Applications
ELISA
Flow Cytometry
Immunoprecipitation
Radioimmunoassay
Western Blotting
Application Notes
ELISA
Flow Cytometry
Western Blotting: non reducing conditions only
Immunoprecipitation
Radioimmunoassay
Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen
Recombinant human tumor necrosis factor receptor type 1
Epitope
Extracellular Domain
Clone
H398
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Specificity
Recognizes an extracellular domain of the 55 kDa human TNF receptor (p55, TNF-R1, CD120a). No binding occurs to the 75 kDa TNF receptor (CD120b). This antibody inhibits the biological activity of both natural and recombinant human TNFa and TNFbthrough competitive inhibition of TNF binding to TNF-R1. MAB3216-100ug shows potent antagonistic activity in in vitro TNF mediated cytotoxicity assays (IC50=12nM; IC50=1.7 mg/mL).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.
FUNCTION: SwissProt: P19438 # Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. SIZE: 455 amino acids; 50495 Da SUBUNIT: Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Secreted. DOMAIN: SwissProt: P19438 The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE. & Both the cytoplasmic membrane-proximal region and the C- terminal region containing the death domain are involved in the interaction with TRPC4AP (By similarity). PTM: The soluble form is produced from the membrane form by proteolytic processing. DISEASE: "SwissProt: P19438 # Defects in TNFRSF1A are the cause of familial hibernian fever (FHF) [MIM:142680]; also known as tumor necrosis factor receptor-associated periodic syndrome (TRAPS). FHF is an autosomal dominant disease characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia." SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats.
Molecular Weight
~50 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain at 2-8°C in undiluted aliquots for short term or -20°C up to one year.
