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ABS574-AF488 Anti-Surfactant Protein D Antibody, Alexa Fluor® 488 Conjugate

Detect Surfactant Protein D using this rabbit polyclonal Anti-Surfactant Protein D Antibody, Alexa Fluor® 488 Conjugate, Cat. No. ABS574-AF488, validated for use in Immunocytochemistry and Immunofluorescence.

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Research Category: Signaling Gene Symbol: SFTPD, COLEC7, PSPD, SFTP4 UniProt Number: P35247
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ABS574-AF488
100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HICC, IFRbAlexaFluor®488Polyclonal Antibody
      Description
      Catalogue NumberABS574-AF488
      DescriptionAnti-Surfactant Protein D Antibody, Alexa Fluor® 488 Conjugate
      Alternate Names
      • Pulmonary surfactant-associated protein D
      • Collectin-7
      • Lung surfactant protein D
      • PSP-D
      • SP-D
      Background InformationPulmonary surfactant-associated protein D (UniProt P35247; also known as Collectin-7, Lung surfactant protein D, PSP-D, SP-D) is encoded by the SFTPD (also known as COLEC7, PSPD, SFTP4) gene (Gene ID 6441) in human. Surfactant, produced by alveolar type II cells and airway Clara cells, resides at the air-liquid interface of the lungs and is most commonly known for its role in reducing surface tension. Surfactant is a lipoprotein complex composed of approximately 10% proteins, including surfactant protein A (SP-A), SP-B, SP-C, and SP-D. SP-A and SP-D belong to the collectin family of proteins and can modulate innate immunity. SP-D is known to enhance pulmonary clearance of pathogens, such as Pseudomonous aerginosa, Klebsiella pneumonia, respiratory syncytial virus (RSV) and Influenza virus. SP-D is also shown to modify allergic responsee in the lungs by binding common allergens, including house dust mite and pollen particles. SP-A-deficient and SP-D-deficient mice are susceptible to bleomycin-induced lung injury and display increased cellular inflammation, more severe lung fibrosis, and reduced survival. In addition to lung, SP-D is also reported to be detected in extrapulmonary tissues, such as kidney and pancreas. Serum levels of either SP-A or SP-D in human are correlated with mortality in patients with pulmonary fibrosis. Human SP-D is produced with a signal peptide sequence (a.a. 1-20), which is removed posttranslationally to yield the mature protein (a.a. 21-375) that contains a collagen-like domain (a.a. 46-222), a coiled coil region (a.a. 223-252), and a C-type lectin domain (a.a. 260-375).
      References
      Product Information
      FormatAlexaFluor®488
      PresentationPurified rabbit polyclonal antibody conjugate in PBS with 1.5% BSA and 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Surfactant Protein D using this rabbit polyclonal Anti-Surfactant Protein D Antibody, Alexa Fluor® 488 Conjugate, Cat. No. ABS574-AF488, validated for use in Immunocytochemistry and Immunofluorescence.
      Key Applications
      • Immunocytochemistry
      • Immunofluorescence
      Application NotesImmunofluorescence Analysis: A 1:50 dilution from a representative lot detected surfactant protein D in human lung tissue sections.

      The unconjugated antibody (Cat. No. ABS574) is also available for immunocytochemistry and Western blotting applications.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to a sequence within the C-type lectin domain of human surfactant protein D.
      Epitopedomain of:
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis Alexa Fluor® 488-conjugated polyclonal antibody targets a sequence within the C-type lectin domain of human surfactant protein D.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Target sequence shares 85.7% amino acid identity with the corresponding murine and rat region.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SFTPD
      • COLEC7
      • PSPD
      • SFTP4
      Purification MethodAffinity purified.
      UniProt Number
      Molecular Weight~48 kDa observed. 35.50/37.73 kDa (mature/pro-form) calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry in A549 cells.

      Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected surfactant protein D in A549 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABS574-AF488 04054839086144