Millipore Sigma Vibrant Logo

ABS2238-100UL Anti-SLC25A44

ABS2238-100UL
100 µL  
Preis nicht abrufbar
Die Mindestmenge muss ein Vielfaches sein von
Maximum Quantity is
Bei Bestätigung Weitere Informationen
Sie haben () gespart
 
Bitte erfragen
Eingeschränkte Verfügbarkeit
Eingeschränkte Verfügbarkeit
Lieferbar 
Produkt wurde eingestellt
Begrenzter Lagerbestand
Bestätigung der Verfügbarkeit erforderlich
    Restmenge: Angebot folgt
      Restmenge: Angebot folgt
      Bitte erfragen
      Kontakt zum Kundenservice
      Contact Customer Service

       

      Kontakt zum Kundenservice

      Übersicht

      Description
      Catalogue NumberABS2238-100UL
      DescriptionAnti-SLC25A44
      Alternate Names
      • Solute carrier family 25 member 44
      Background InformationSolute carrier family 25 member 44 (UniProt: Q8BGF9; also known as SLC25A44) is encoded by the Slc25a44 gene (Gene ID: 229517) in murine species. SCL25A44 is a multi-pass mitochondrial membrane protein with six transmembrane domains that is highly expressed in brown adipose tissue. Its expression is shown to increase during adipogenesis. Higher levels of SLC25A44 are observed following exposure to cold. It serves as a transporter for branched-chain amino acids into mitochondria that can be utilized for thermogenesis. Brown adipose fat in Slc25a44 knockout mice displays larger lipid droplets and higher levels of triglycerides. However, the depletion of Slc25a44 does not affect the mitochondrial respiration in brown adipocytes. (Ref.: Yoneshiro, T., et al. (2019). Nature. 572 (7771); 614-619.
      Product Information
      FormatPurified
      PresentationPurified rabbit polyclonal antibody in PBS, pH 7.4, containing 0.02% sodium azide.
      Quality LevelMQ200
      Applications
      ApplicationAnti-SLC25A44, Cat. No. ABS2238, is a rabbit polyclonal antibody that detects Solute carrier family 25 member 44 (SLC25A44) and is tested for use in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: A representative lot detected SLC25A44 in Western Blotting applications (Yoneshiro, T., et. al. (2019). Nature. 572(7771):614-619).

      Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected SLC25A44 in brown adipose tissue of mice with Slc25a44-CRISPRi (knock-down). (Courtesy of Dr Kajimura lab @ University of California,San Francisco).

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
      Biological Information
      ImmunogenKLH-conjugated linear peptides corresponding to 20 amino acids from the N-terminal region, 14 amino acids from the internal region, and 14 amino acids from the C-terminal region of mouse Solute carrier family 25 member 44 (SLC25A44).
      EpitopeUnknown
      Concentration0.5 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostRabbit
      SpecificityThis rabbit polyclonal antibody detects Solute carrier family 25 member 44 (SLC25A44) in multiple species.
      IsotypeIgG
      Species Reactivity
      • Mouse
      Species Reactivity NoteMouse. Predicted to react with Bovine, Human, Monkey, Xenopus based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SLC25A4
      • ANT1
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight~35 kDa observed; 35.34 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in brown adipose tissue lysate.

      Western Blotting Analysis: A 1:200 dilution of this antibody detected SLC25A44 in brown adipose tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at +2°C to +8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Global Trade Item Number
      Bestellnummer GTIN
      ABS2238-100UL 04061841879909