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AP1134 Anti-SET Mouse mAb (M1-F5)

Anti-SET Mouse mAb (M1-F5): SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: Anti-HLA-DR- Associated Protein II

AP1134
  
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      Replacement Information

      Key Spec Table

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      Description
      Overview

      This product has been discontinued.





      Recognizes the ~56-58 kDa SET protein.
      Catalogue NumberAP1134
      Brand Family Calbiochem®
      SynonymsAnti-HLA-DR- Associated Protein II
      Application Data
      Detection of human SET by immunoblotting. Sample: Recombinant human SET. Primary antibody: Anti-SET Mouse mAb (M1-F5) (Cat. No. AP1134) (1-5 µg/ml). Detection: chemiluminescence.
      References
      Product Information
      Formliquid
      FormulationIn PBS, pH 7.2.
      PreservativeNone
      Applications
      Key Applications Enzyme-Linked Immunosorbent Assay
      Immunoblotting (Western Blotting)
      Application NotesELISA (see comments)
      Immunoblotting (1-5 µg/ml)
      Application CommentsFor ELISA, this antibody can be used as the capture antibody; recommended starting concentration is 10 µg/ml, 1 µg/well, 100 µl total volume per well. Variables associated with assay conditions will dictate the proper working dilution.
      Biological Information
      ImmunogenFull-length, recombinant human SET (aa1-278) expressed as a GST fusion protein
      ImmunogenNA
      CloneM1-F5
      HostMouse
      IsotypeIgG1
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Regulatory Review
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      AP1134 0

      Documentation

      Anti-SET Mouse mAb (M1-F5) Analysenzertifikate

      TitelChargennummer
      AP1134
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-October-2010 JLN
      SynonymsAnti-HLA-DR- Associated Protein II
      ApplicationELISA (see comments)
      Immunoblotting (1-5 µg/ml)
      Application Data
      Detection of human SET by immunoblotting. Sample: Recombinant human SET. Primary antibody: Anti-SET Mouse mAb (M1-F5) (Cat. No. AP1134) (1-5 µg/ml). Detection: chemiluminescence.
      DescriptionPurified mouse monoclonal antibody. Recognizes the ~56-58 kDa SET protein.
      BackgroundSET is a multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. There are two known isoforms, both of which serve as potent inhibitors of protein phosphatase 2A. Furthermore, both isoforms inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. Unlike isoform 1 characteristics, isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition.
      HostMouse
      Immunogen speciesNA
      ImmunogenFull-length, recombinant human SET (aa1-278) expressed as a GST fusion protein
      CloneM1-F5
      IsotypeIgG1
      Specieshuman
      Formliquid
      FormulationIn PBS, pH 7.2.
      PreservativeNone
      CommentsFor ELISA, this antibody can be used as the capture antibody; recommended starting concentration is 10 µg/ml, 1 µg/well, 100 µl total volume per well. Variables associated with assay conditions will dictate the proper working dilution.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Regulatory Review