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MABF2038-25UG Anti-Rabies virus Antibody, clone 802

This mouse monoclonal Anti-Rabies virus, clone 802, Cat. No. MABF2038, is a mouse monoclonal antibody that detects glycoprotein of Rabies virus and has been tested for use in Immunohistochemistry.

Anti-Rabies virus Antibody, clone 802: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Inflammation & Immunology UniProt Number: P03524
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MABF2038-25UG
25 μg  
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      Übersicht

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      VirusIHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF2038-25UG
      DescriptionAnti-Rabies virus Antibody, clone 802
      Alternate Names
      • Glycoprotein G Rabies Virus
      Background InformationGlycoprotein (UniProt: P03524) of Rabies virus of Evelyn-Rokitnicki-Abelseth (ERA) strain is encoded by the G gene. Rabies virus belongs to the Lyssavirus serogroup of viruses. The glycoprotein of Rabies virus is a homotrimer, single-pass type I membrane protein that attaches the virus to host cellular receptor and thereby inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. It has been shown that the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and facilitate Rabies virus entry into cells. Arginine 352 is considered to be highly involved in Rabies virus pathogenicity and a mutation at this site dramatically attenuates the virus. Rabies virus glycoprotein is synthesized with a signal peptide (aa 1-19) that is subsequently cleaved off. It has two topological domains (aa 20-459 virion surface; 481-524 intravirion) and a helical domain (aa 460-480). Glycosylation of viral glycoprotein is considered to be crucial for glycoprotein export at the cell surface. Clone 802 is shown to recognize most Rabies virus strains, however it does not display neutralizing activity. (Ref.: Schumacher, CL et al. (1989). J. Clin. Invest. 84(3); 971-975; Bunschoten, H et al. (1989). J. Gen. Virol. 70(2); 291-298).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG2b in PBS without preservatives.
      Applications
      ApplicationThis mouse monoclonal Anti-Rabies virus, clone 802, Cat. No. MABF2038, is a mouse monoclonal antibody that detects glycoprotein of Rabies virus and has been tested for use in Immunohistochemistry.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A representative lot detected Rabies virus in CVS-24 infected mouse and normal mouse tissues (Courtesy of the Ertl Lab, Wistar Institute, Philadelphia, PA USA).
      Biological Information
      ImmunogenBeta-propiolactone-inactivated Rabies Virus (ERA strain).
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 802 detects Glycoprotein of Rabies virus (strain ERA). This clone does not display neutralizing activity in vitro.
      IsotypeIgG2b
      Species Reactivity
      • Virus
      Species Reactivity NoteRabies Virus.
      Antibody TypeMonoclonal Antibody
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight58.6 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceIsotype testing: Identity Confirmation by Isotyping Test.
      Isotyping Analysis: The identity of this monoclonal antibody is confirmed by isotyping test to be mouse IgG2b.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABF2038-25UG 04054839497049