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ABE1959 Anti-RAD9A Antibody

Anti-RAD9A Antibody, Cat. No. ABE1959, is a highly specific rabbit polyclonal antibody that targets RAD9A and has been tested in Immunohistochemistry (Paraffin).

Anti-RAD9A Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Epigenetics & Nuclear Function Gene Symbol: Rad9a, Rad9 UniProt Number: Q9Z0F6
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ABE1959
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIH(P)RbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE1959
      DescriptionAnti-RAD9A Antibody
      Alternate Names
      • Cell cycle checkpoint control protein RAD9A
      • DNA repair exonuclease rad9 homolog A
      • hRAD9
      • mRAD9
      • Rad9-like protein
      Background InformationCell cycle checkpoint control protein RAD9A (EC 3.1.11.2; UniProt Q9Z0F6; also known as DNA repair exonuclease rad9 homolog A, mRAD9, Rad9-like protein) is encoded by the Rad9a (also known as Rad9) gene (Gene ID 19367) in murine species. RAD9A is a component of the trimeric PCNA-like 9-1-1 complex (Rad9A, Rad1, and Hus1) and plays an important role in maintaining genomic integrity. RAD9A participates in both ATR and ATM signaling pathways-mediated cell cycle checkpoints in mitosis. Evidences indicate that RAD9A participates in DNA damage repair by interacting with proteins involved in base excision repair, mismatch repair and homologous recombination repair. RAD9A is shown to colocalize with γH2AX following DNA damage induction in an ATM-independent manner, and RAD9A inactivation delays the appearance of ionizing radiation-induced γH2AX foci. Rad9a-knockout causes embryonic lethality in mice due to increased apoptotic activity and reduced cellular proliferation, while mice heterozygous for Rad9a are prone to spontaneous and radiation-induced cataractogenesis. In addition, conditional knockout in keratinocytes causes enhanced susceptibility to carcinogen-induced skin tumors, while conditional Rad9a deletion in undifferentiated spermatogonia results in drastic effects on meiosis.
      References
      Product Information
      FormatPurified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-RAD9A Antibody, Cat. No. ABE1959, is a highly specific rabbit polyclonal antibody that targets RAD9A and has been tested in Immunohistochemistry (Paraffin).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution of from a representative lot detected RAD9A in mouse spleen tissue section.

      Immunohistochemistry Analysis: A representative lot detected strong RAD9A immunoreactivity in the nuclei of prophase spermatocytes, lower immunoreactivity was also seen in Sertoli cells, while little or no staining of spermatids and spermatogonia was seen in 3.7% paraformaldehyde-fixed, paraffin-embedded mouse testis tissue sections (Vasileva, A., et al. (2013). J. Cell Sci. 126(Pt 17):3927-3938).
      Biological Information
      ImmunogenGST-tagged recombinant full-length mouse RAD9A.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis rabbit polyclonal antibody detected nuclear RAD9A immunoreactivity in human and mouse tissue sections.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteHuman, Mouse.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Rad9a
      • Rad9
      Purification MethodProtein A purified.
      UniProt Number
      Molecular Weight42.55/42.06 kDa (human/mouse) calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human prostate cancer tissue.

      Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected RAD9A in human prostate cancer tissue section.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt..
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABE1959 04054839086151