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07-1225 Anti-PP5 Antibody

Detect PP5 using this Anti-PP5 Antibody validated for use in WB, IH(P).

Anti-PP5 Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Signaling Research Sub-Category: Kinases & Phosphatases Gene Symbol: PPP5C, PPP5, FLJ36922, PP-T, PP5, PPT, EC 3.1.3.16 UniProt Number: P53041
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07-1225
100 µg  
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      Übersicht

      Replacement Information
      Replacement Information07-1225 is a recommended replacement for AB4092

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IH(P)RbPurifiedPolyclonal Antibody
      Description
      Catalogue Number07-1225
      ReplacesAB4092
      Trade Name
      • Upstate
      DescriptionAnti-PP5 Antibody
      Alternate Names
      • Protein phosphatase T
      • Serine/Threonine phosphatase
      • Serine/threonine-protein phosphatase 5
      • Protein phosphatase 5, catalytic subunit
      Background InformationProtein phosphatase 5 (PP5) is a novel human protein serine/threonine phosphatase of molecular weight of 58 kDa. It is made up of a C-terminal phosphatase catalytic domain and an N-terminal domain, which has four repeats of 34 amino acids, three of which are tandemly arranged. The phosphatase domain contains all of the invariant motifs of the PP1/PP2A/PP2B gene family. However, it is not closely related to any other known member of this family of phosphatases. Thus it makes up a new subfamily of phosphatases. PP5 expressed in bacteria has been shown to dephosphorylate serine residues in proteins and is more sensitive than PP1 to the tumor promoter okadaic acid. PP5 appears to be localized to the nucleus where it is thought to play a roll in the regulation of RNA biogenesis and mitosis as part of a signaling pathway regulating cell cycle progression.
      References
      Product Information
      FormatPurified
      Control
      • Jurkat Cell Lysate, A549 and MCF-7 cell lysates.
      PresentationPurified rabbit polyclonal IgG in phosphate buffered saline with 0.08% sodium azide
      Quality LevelMQ100
      Applications
      ApplicationDetect PP5 using this Anti-PP5 Antibody validated for use in WB, IH(P).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry(paraffin):
      Representative images from a previous lot.

      Optimal Staining of PP5 Polyclonal Antibody: Human Testis
      Biological Information
      ImmunogenSynthetic peptide derived from the human protein phosphatase 5 protein.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes Protein Phosphatase 5 (PP5).
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PPP5C
      • PPP5
      • FLJ36922
      • PP-T
      • PP5
      • PPT
      • EC 3.1.3.16
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P53041 # May play a role in the regulation of RNA biogenesis and/or mitosis. In vitro, dephosphorylates serine residues of skeletal muscle phosphorylase and histone H1.
      COFACTOR: Binds 1 iron ion per subunit (By similarity). & Binds 1 manganese ion per subunit (By similarity).
      SIZE: 499 amino acids; 56879 Da
      SUBUNIT: Interacts with CDC16 and CDC27.
      SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly nuclear. But also present in the cytoplasm.
      TISSUE SPECIFICITY: Ubiquitous.
      SIMILARITY: SwissProt: P53041 ## Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. & Contains 3 TPR repeats.
      Molecular Weight58 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by Western Blot on Jurkat lysates.

      Western Blot Analysis: 1:500 dilution of this lot detected PP-5 on 10 μg of Jurkat lysates
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 1 year from date of receipt.
      Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      07-1225 04053252373138