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PC367 Anti-PL-Scramblase (309-317) Rabbit pAb

Anti-PL-Scramblase (309-317) Rabbit pAb: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: Anti-Phospholipid Scramblase

PC367
  
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      Übersicht

      Replacement Information

      Key Spec Table

      Host
      Rb
      Description
      Overview

      This product has been discontinued.





      This product has been discontinued.





      Recognizes the ~50 kDa (apparent MW) PL-Scramblase protein in colon carcinoma and normal skin tissue.
      Catalogue NumberPC367
      Brand Family Calbiochem®
      SynonymsAnti-Phospholipid Scramblase
      References
      ReferencesBevers, E.M., et al. 1998. Lupus 7 Suppl 2, S126.
      Dekkers, D.W., et al. 1998. Blood 91, 2131.
      Stout, J.G., et al. 1998. Biochemistry 37, 14860.
      Zhao, J, et al. 1998. Biochemistry 37, 6361.
      Zhou, Q., et al. 1998. Blood 92, 1707.
      Zhou, Q., et al. 1998. Biochemistry 37, 2356.
      Zhou, Z., et al. 1997. J. Biol. Chem. 272, 18240.
      Product Information
      FormLiquid
      FormulationIn 0.05 M sodium phosphate buffer, 0.2% gelatin.
      Negative controlNormal rabbit IgG
      Positive controlColon carcinoma or normal skin tissue
      Preservative≤0.1% sodium azide
      Applications
      Application ReferencesImmunoblotting Yu, a., et al. 2004. Biochem. J. 381, 609.
      Key Applications Immunoblotting (Western Blotting)
      Paraffin Sections
      Application NotesImmunoblotting (1 µg/ml, see application references)
      Paraffin Sections (2.5 µg/ml, heat or pressure cooker pre-treatment required)
      Application CommentsThe calculated molecular weight is ~35, but migrates at ~50 kDa on SDS-PAGE. Antibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogena synthetic peptide corresponding to amino acids 309-317 of human PL-scramblase
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Yes
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      PC367 0

      Documentation

      Anti-PL-Scramblase (309-317) Rabbit pAb Analysenzertifikate

      TitelChargennummer
      PC367

      Literatur

      Übersicht
      Bevers, E.M., et al. 1998. Lupus 7 Suppl 2, S126.
      Dekkers, D.W., et al. 1998. Blood 91, 2131.
      Stout, J.G., et al. 1998. Biochemistry 37, 14860.
      Zhao, J, et al. 1998. Biochemistry 37, 6361.
      Zhou, Q., et al. 1998. Blood 92, 1707.
      Zhou, Q., et al. 1998. Biochemistry 37, 2356.
      Zhou, Z., et al. 1997. J. Biol. Chem. 272, 18240.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-October-2007 RFH
      SynonymsAnti-Phospholipid Scramblase
      ApplicationImmunoblotting (1 µg/ml, see application references)
      Paraffin Sections (2.5 µg/ml, heat or pressure cooker pre-treatment required)
      DescriptionPurified rabbit polyclonal antibody. Recognizes the ~50 kDa (apparent MW) PL-Scramblase protein.
      BackgroundPhospholipid scramblase (PL-scramblase) is a ~35 kDa protein that mediates the accelerated transbilayer migration of plasma membrane phospholipid in both injured and apoptotic cells. The activity of PL-scramblase and the transmembrane movement is Ca2+ dependent/ATP independent and has a marked preference for phosphatidyl serine. Other cations have been shown to substitute for Ca2+ notably Tb3+ and La3+. Both the murine and the human genes have been cloned. One key difference between the two is the short exocytoplasmic tail in the human protein compared to a membrane inserted segment in the mouse protein. Palmitoylation of PL-scramblase is required for anchoring in the cell membrane where it is localized. Notable is the activation and upregulation of PL-scramblase in response to apoptotic signals early in the apoptotic response. This activation and upregulation is required for the subsequent appearance of phosphatidyl serine on the external membrane surface of apoptotic cells. PL-scramblase also has a role in disease; a defect in the ability to activate the PL-scramblase pathway is the basis for Scott syndrome, an inherited bleeding disorder.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide corresponding to amino acids 309-317 of human PL-scramblase
      IsotypeIgG
      Specieshuman, mouse
      Positive controlColon carcinoma or normal skin tissue
      Negative controlNormal rabbit IgG
      FormLiquid
      FormulationIn 0.05 M sodium phosphate buffer, 0.2% gelatin.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative≤0.1% sodium azide
      CommentsThe calculated molecular weight is ~35, but migrates at ~50 kDa on SDS-PAGE. Antibody should be titrated for optimal results in individual systems.
      Storage +2°C to +8°C
      Do Not Freeze Yes
      Toxicity Standard Handling
      ReferencesBevers, E.M., et al. 1998. Lupus 7 Suppl 2, S126.
      Dekkers, D.W., et al. 1998. Blood 91, 2131.
      Stout, J.G., et al. 1998. Biochemistry 37, 14860.
      Zhao, J, et al. 1998. Biochemistry 37, 6361.
      Zhou, Q., et al. 1998. Blood 92, 1707.
      Zhou, Q., et al. 1998. Biochemistry 37, 2356.
      Zhou, Z., et al. 1997. J. Biol. Chem. 272, 18240.
      Application referencesImmunoblotting Yu, a., et al. 2004. Biochem. J. 381, 609.