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MABN609 Anti-OCRL/INPP5b Antibody, clone N166A/26

Detect Inositol polyphosphate 5-phosphatase OCRL-1 using this mouse monoclonal antibody, Anti-OCRL/INPP5b Antibody, clone N166A/26 validated for use in western blotting & IHC.

Anti-OCRL/INPP5b Antibody, clone N166A/26: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: OCRL, INPP5F, OCRL1 UniProt Number: Q01968
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MABN609
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN609
      DescriptionAnti-OCRL/INPP5b Antibody, clone N166A/26
      Alternate Names
      • Inositol polyphosphate 5-phosphatase OCRL-1
      • Lowe oculocerebrorenal syndrome protein
      Background InformationInositol polyphosphate 5-phosphatase OCRL-1 (ORCL) is also called Lowe oculocerebrorenal syndrome protein. ORCL is a phosphotase that converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate, as well as inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate. ORCL is involved in primary cilia assembly and may also have a role in lysosomal membrane trafficking. ORCL is expressed in brain, skeletal muscle, heart, kidney, lung, placenta, fibroblasts, retina and the retinal pigment epithelium. OCRL defects can cause Lowe oculocerebrorenal syndrome (OCRL) and Dent disease type 2 (DD2).
      References
      Product Information
      FormatPurified
      Control
      • Rat brain tissue lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Inositol polyphosphate 5-phosphatase OCRL-1 using this mouse monoclonal antibody, Anti-OCRL/INPP5b Antibody, clone N166A/26 validated for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blotting Analysis: 0.5 µg/mL from a representative lot detected OCRL/INPP5b in 10 µg of rat brain tissue lysate.
      Western Blotting Analysis: A representative lot detected OCRL/INPP5b in COS cell lysates transiently transfected with GFP-tagged OCRL or RFP-tagged INPP5b, and demonstrated a loss of signal in COS cell lysates transiently transfected with untagged Kv2.1 plasmids (Prof. J. Trimmer, University of California, Davis.).
      Immunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected OCRL/INPP5b in human cerebellum and human cardiac myocytes.
      Biological Information
      ImmunogenRecombinant protein corresponding to human OCRL/INPP5b.
      CloneN166A/26
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityCross-reacts with OCRL/INPP5b (Prof. J. Trimmer, Univerity of California, Davis).
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • OCRL
      • INPP5F
      • OCRL1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~104 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human brain tissue lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected OCRL/INPP5b in 10 µg of human brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABN609 04053252915376