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MABS1703 Anti-MGAT2 Antibody, clone 4A5.2

Detect MGAT2 using this mouse monoclonal Anti-MGAT2 Antibody, clone 4A5.2, Cat. No. MABS1703, validated for use in Western Blotting.

Anti-MGAT2 Antibody, clone 4A5.2: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Signaling Gene Symbol: MGAT2, CDG2A UniProt Number: Q10469
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MABS1703
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS1703
      DescriptionAnti-MGAT2 Antibody, clone 4A5.2
      Alternate Names
      • Alpha-1
      • 6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
      • Beta-1
      • 2-N-acetylglucosaminyltransferase II
      • GlcNAc-T II
      • GNT-II
      • Mannoside acetylglucosaminyltransferase 2
      • N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
      Background InformationAlpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143; UniProt Q10469; also known as Beta-1,2-N-acetylglucosaminyltransferase II, GlcNAc-T II, GNT-II, Mannoside acetylglucosaminyltransferase 2, MGAT2, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyl-transferase II) is encoded by the MGAT2 (also known as CDG2A) gene (Gene ID 4247) in human. MGAT2 is a Golgi enzyme that catalyzes an essential step in the conversion of oligo-mannose to complex N-glycans. It possesses the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. It is highly expressed in small intestine in mice and humans. Mutations in MGTA2 gene are known to cause congenital disorders of glycosylation 2A, which is a multi-system disorder caused by defective glycoprotein biosynthesis. It leads to under-glycosylated levels of serum glycoproteins that result in defects in neuronal development, coagulation disorders, hypotonia, and immunodeficiency.

      Ref.:
      Tan, J., et al. (1995). Eur. J. Biochem. 231, 317-328.
      Tan J., et al. (1996), Am. J. Hum. Genet. 159, 810-817.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect MGAT2 using this mouse monoclonal Anti-MGAT2 Antibody, clone 4A5.2, Cat. No. MABS1703, validated for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged internal fragment from the C-terminal half of human MGAT2.
      Clone4A5.2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 4A5.2 targets an internal epitope within the C-terminal half of human MGAT2.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MGAT2
      • CDG2A
      Purification MethodProtein G purified.
      UniProt Number
      Molecular Weight~52 kDa observed. 51.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in T47D cell lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected MGAT2 in 10 µg of T47D cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABS1703 04054839114519