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ABE1436 Anti-KAT7 Antibody (HBO1 / MYST2)

Anti-KAT7 (HBO1 / MYST2), Cat. No. ABE1436, is a highly specific rabbit polyclonal antibody that targets histone acetyltransferase KAT7 and has been tested in Immunocytochemistry and Western Blotting.

Anti-KAT7 Antibody (HBO1 / MYST2): SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Epigenetics & Nuclear Function Gene Symbol: Kat7, Hbo1, Myst2 UniProt Number: Q5SVQ0
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ABE1436
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, MICC, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE1436
      DescriptionAnti-KAT7 Antibody (HBO1 / MYST2)
      Alternate Names
      • Histone acetyltransferase KAT7
      • Histone acetyltransferase binding to ORC1
      • Lysine acetyltransferase 7
      • MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
      Background InformationHistone acetyltransferase KAT7 (EC 2.3.1.48; UniProt Q5SVQ0; also known as Histone acetyltransferase binding to ORC1, Lysine acetyltransferase 7, MOZ, MYST-2, SAS2 and TIP60 protein 2, YBF2/SAS3) is encoded by the Kat7 (also known as Hbo1, Myst2) gene (Gene ID 217127) in murine species. KAT7 is a MYST ( MOZ, Ybf2/Sas3, Sas2, and Tip60) family histone acetyltransferase (HAT) originally characterized as a HAT bound to origin recognition complex 1 (ORC1) and named HBO1. KAT7 displays histone H4-specific acetyltransferase activity with reduced activity toward histone H3. KAT7 plays an essential role in adipogenesis, embryonic development, and the survival of erythroblasts in fetal liver. KAT7 interacts with two JADE1 isoforms, JADE1S and JADE1L, that promote KAT7-mediated acetylation of nucleosomal histones. The KAT7-JADE1 complex shows cell cycle-dependent chromatin shuttling during mitosis via a mechanism linked to JADE1 phosphorylation. Nuclear JADE1S and HBO1 localization correlates with that of cell proliferation marker Ki67 and bulk histone H4 acetylation. KAT7 upregulation has been reported in some human cancers and tumor suppressor p53 expression suppresses KAT7 HAT activity.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-KAT7 (HBO1 / MYST2), Cat. No. ABE1436, is a highly specific rabbit polyclonal antibody that targets histone acetyltransferase KAT7 and has been tested in Immunocytochemistry and Western Blotting.
      Key Applications
      • Immunocytochemistry
      • Western Blotting
      Application NotesImmunocytochemistry Analysis: A 1:1,000 dilution from a representative lot detected KAT7 (HBO1/MYST2) in HeLa cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to a central region sequence within the N-terminal half of human/mouse/rat KAT7 (HBO1/MYST2).
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis rabbit polyclonal antibody targets a central region sequence present in all human, murine, and rat KAT7 (HBO1/MYST2) spliced isoforms reported by UniProt (O95251, Q5SVQ0, Q810T5).
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Species Reactivity NoteHuman, Mouse, Rat. Predicted to react with Porcine, Chicken, Bovine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Kat7
      • Hbo1
      • Myst2
      Purification MethodAffinity purified.
      UniProt Number
      Molecular Weight~83 kDa observed. 70.64/58.14/51.44/66.95/55.14 kDa (human isoform 1/2/3/4/5), 70.64/66.95/70.61/66.92/60.25 kDa (mouse isoform 1/2/3/4/5), and 70.51/66.82 kDa (rat isoform 1/2) calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in L6 myoblast lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected KAT7 (HBO1/MYST2) in 10 µg of L6 rat myoblast lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABE1436 04054839086120