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MABS1984 Anti-INTS1 Antibody, clone 4.47

Anti-INTS1, clone 4.47 Antibody, Cat. No. MABS1984, is a highly specific mouse monoclonal antibody, that targets INTS1 and has been tested in Western Blotting.

Anti-INTS1 Antibody, clone 4.47: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Epigenetics & Nuclear Function Gene Symbol: INTS1, KIAA1440, UNQ1821/PRO3434 UniProt Number: Q8N201
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MABS1984
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS1984
      DescriptionAnti-INTS1 Antibody, clone 4.47
      Alternate Names
      • Integrator complex subunit 1
      • Int1
      Background InformationIntegrator complex subunit 1 (UniProt Q8N201; also known as Int1) is encoded by the INTS1 (also known as KIAA1440, UNQ1821/PRO3434) gene (Gene ID 26173) in human. INTS1 is a large protein that is a component of the integrator complex that is involved in small nuclear RNAs U1 and U2 transcription and their 3'-box-dependent processing. During transcriptional regulation and in RNA processing, it directly binds to the C-terminal domain of the RNA polymerase II largest subunit. It has been reported that INTS1 is also involved in different cell support processes, such as the formation of a scaffold for the assembly of integrator complex. Developing INTS1 (-/-) mouse embryos show growth arrest at the early blastocyst stage and exhibit activated caspase-3 and caspase-7 that induce apoptosis within the inner cell mass of blastocyst.

      Ref.:
      Baillat, D et al. (2005). Cell 123, 265-276.
      Hata T., and Nakayama, M (2007), Biochim. Biophys. Acta 1773, 1039-1051.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-INTS1, clone 4.47 Antibody, Cat. No. MABS1984, is a highly specific mouse monoclonal antibody, that targets INTS1 and has been tested in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant human INTS1 internal fragment.
      Clone4.47
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 4.47 targets an epitope in the central region of human INTS1 protein.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • INTS1
      • KIAA1440
      • UNQ1821/PRO3434
      Purification MethodProtein G purified.
      UniProt Number
      Molecular Weight~240 kDa observed. 244.3 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected in 50 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABS1984 04054839114502