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MABN543 Anti-Gs protein Antibody, alpha subunit, clone N192/12

Anti-Gs protein Antibody, alpha subunit, clone N192/12 is a highly specific mouse monoclonal antibody & that targets Gsα & has been tested in western blotting.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: GNAS, GNAS1 UniProt Number: P04896
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MABN543
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN543
      DescriptionAnti-Gs protein Antibody, alpha subunit, clone N192/12
      Alternate Names
      • Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
      • Adenylate cyclase-stimulating G alpha protein
      Background InformationThe heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) mediate signaling from a large number of G-protein coupled receptors (GPCR) to a variety of intracellular effectors. G-proteins are composed of a 36-52 kDa α-subunit, a 35-36 kDa β-subunit, and an 8-10 kDa γ-subunit. They are classified based on the nature of their α-subunit. Gs is ubiquitously expressed and couples receptors to adenylyl cyclase and promotes intracellular cAMP generation. Mutations in Gs-α can lead to constitutive activation of receptors leading to development of endocrine tumors, fibrous dysplasia of bone, and McCune-Albright syndrome. In brain tissue Gs-α activates adenyl cyclase in direct response to stimulation of several neurotransmitter receptors and facilitates depolarization-induced neurotransmitter release for synaptic transmission. Also, it is shown that Gs-stimulated adenylyl cyclase activity is significantly reduced in the Alzheimer's disease brain tissue.
      References
      Product Information
      FormatPurified
      Control
      • Rat brain membrane tissue lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Gs protein Antibody, alpha subunit, clone N192/12 is a highly specific mouse monoclonal antibody & that targets Gsα & has been tested in western blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: 2.0 µg/mL from a representative lot detected GS protein, alpha subunit in 10 µg of SH-SY5Y cell lysate.
      Biological Information
      ImmunogenRecombinant protein corresponding to bovine GS protein, alpha subunit.
      CloneN192/12
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Rat
      Species Reactivity NoteDemonstrated to react with Human and Rat. Predicted to react with Bovine based on immunogen design. Other homologies: Mouse (99% sequence homology).
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GNAS
      • GNAS1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~45 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat brain membrane tissue lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected GS protein, alpha subunit in 10 µg of rat brain membrane tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABN543 04053252888618

      Documentation

      Anti-Gs protein Antibody, alpha subunit, clone N192/12 SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Anti-Gs protein Antibody, alpha subunit, clone N192/12 Analysenzertifikate

      TitelChargennummer
      Anti-Gs protein, alpha subunit, clone -2807771 2807771
      Anti-Gs protein, alpha subunit, clone N192/12 - Q2166805 Q2166805
      Anti-Gs protein, alpha subunit, clone N192/12 - 3243454 3243454
      Anti-Gs protein, alpha subunit, clone N192/12 - 3385853 3385853
      Anti-Gs protein, alpha subunit, clone N192/12 - 3497289 3497289
      Anti-Gs protein, alpha subunit, clone N192/12 - 3602274 3602274
      Anti-Gs protein, alpha subunit, clone N192/12 - 3738499 3738499
      Anti-Gs protein, alpha subunit, clone N192/12 - 3821796 3821796
      Anti-Gs protein, alpha subunit, clone N192/12 - 4000391 4000391
      Anti-Gs protein, alpha subunit, clone N192/12 - 4112546 4112546
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