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07-1402-I Anti-GLUT-2

Detect GLUT-2 using this rabbit polyclonal Anti-GLUT-2 purified Antibody, Cat. No. 07-1402-I, validated for use in Western Blotting.

Anti-GLUT-2: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Signaling Gene Symbol: Slc2a2, Glut-2, Glut2 UniProt Number: P14246
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07-1402-I
100 μg  
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      Übersicht

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, M, HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-1402-I
      DescriptionAnti-GLUT-2
      Alternate Names
      • Solute carrier family 2
      • facilitated glucose transporter member 2
      • Glucose transporter type 2
      • liver
      • GLUT-2
      Background InformationSolute carrier family 2, facilitated glucose transporter member 2 (UniProt P14246; also known as Glucose transporter type 2, liver, GLUT-2) is encoded by the Slc2a2 (also known as Glut-2, Glut2) gene (Gene ID 20526) in murine species. GLUTs (Glucose transporters) are a family of integral membrane glycoproteins that facilitative glucose uptake by cells. Molecular cloning of glucose transporters have identified a family of closely related genes that encode at least 7 proteins exhibiting high degree of homology (45% to 65%). GLUT2 is a facilitative glucose transporter that mediates the bidirectional transfer of glucose across the hepatocyte membrane. It is present at high levels in the plasma membrane of pancreatic beta cells where it initiates the first step in glucose-stimulated insulin secretion. Due to its low affinity and high capacity, GLUT2 transports dietary sugars, glucose, fructose and galactose in a large range of physiological concentrations, displaying large bidirectional fluxes in and out the cells. It also participates in the transport of glucose in small intestine and kidney along with the Na+/glucose cotransporter. Hepatic GLUT2 expression is upregulated in a dose-dependent manner according to glucose concentration in primary hepatocytes and hepatocyte cell lines. Also, hepatic GLUT2 expression is reduced during starvation and returns to normal levels after refeeding. In diabetic animals, hepatic GLUT2 expression is increased, but is corrected to normal levels when hyperglycemic conditions are corrected by exogenous insulin.

      Ref.: Burkhardt, BR., et al. (2005). FEBS Lett. 579, 5759 5764.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect GLUT-2 using this rabbit polyclonal Anti-GLUT-2 purified Antibody, Cat. No. 07-1402-I, validated for use in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: 1 µg/mL from a representative lot detected GLUT-2 in 10 µg of human (A431, HEK293, HeLa, HepG2, HUVEC, Jurkat, PC3), mouse (C2C12, NIH/3T3, Raw 264.7), rat (L6, PC12) cell lysates and mouse brain tissue homogenate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to a 16-a.a. sequence within the first extracellular loop of mouse GLUT-2.
      Epitopedomain of:
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis polyclonal antibody targets a region within the first extracellular loop of human, mouse, and rat GLUT-2.
      Species Reactivity
      • Rat
      • Mouse
      • Human
      Species Reactivity NoteHuman, Mouse, Rat.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Slc2a2
      • Glut-2
      • Glut2
      Purification MethodAffinity purified.
      UniProt Number
      Molecular Weight~50 kDa oberved. 57.49/57.11/57.09 kDa (human/mouse/rat) calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HEK293 cell lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected GLUT-2 in 10 µg of HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      07-1402-I 04054839132971