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MABT1565-100UG Anti-Desmin Antibody, clone DE-U-10

This mouse monoclonal Anti-Desmin, clone DE-U-10, Cat. No. MABT1565 is tested for use in Western Blotting, Immunofluorescence, and ELISA, for the detection of Desmin.

NeuMABT1565-100UG
100 μg  
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      Übersicht

      Replacement Information
      Description
      Catalogue NumberMABT1565-100UG
      DescriptionAnti-Desmin Antibody, clone DE-U-10
      Alternate Names
      • CMD1I
      • CSM1
      • CSM2
      Background InformationDesmin (UniProt: P02540) is encoded by the DES gene (Gene ID: 396725) in porcine. Desmin is a type III intermediate filament protein that is essential for maintaining the structural and functional integrity of muscle cells as part of the cytoskeletal network. It provides mechanical support to the muscle cells and facilitates the organization of contractile proteins within the cell. Additionally, it is involved in various cellular processes, including cell signaling, maintenance of cell shape, and intracellular transport. It is particularly abundant in cardiac, skeletal, and smooth muscle tissues. It is also enriched at postsynaptic membranes of neuromuscular junctions (NMJs). Mutations in the gene encoding Desmin have been associated with hereditary and sporadic myopathies, cardiomyopathies and myasthenic syndrome. (Ref.: Eiber, N., et al., (2020). Front. Mol. Neurosci. 13; Article 567084).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ200
      Applications
      ApplicationThis mouse monoclonal Anti-Desmin, clone DE-U-10, Cat. No. MABT1565 is tested for use in Western Blotting, Immunofluorescence, and ELISA, for the detection of Desmin.
      Key Applications
      • Western Blotting
      • Immunofluorescence
      • ELISA
      Application NotesTested Applications

      Western Blotting Analysis: A 1:500 dilution from a representative lot detected Desmin in human skeletal muscle tissue extracts.

      ELISA Analysis: A representative lot detected Desmin in ELISA applications (Debus, E., et al. (1983). EMBO J. 2(12):2305-12).

      Western Blotting Analysis: A representative lot detected Desmin in Western Blotting applications (Debus, E., et al. (1983). EMBO J. 2(12):2305-12).

      Immunofluorescence Analysis: A representative lot detected Desmin in Immunofluorescence applications (Debus, E., et al. (1983). EMBO J. 2(12):2305-12).

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.
      Biological Information
      ImmunogenPurified full length porcine Desmin.
      EpitopeC-terminal half
      CloneDE-U-10
      Concentration0.5 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostMouse
      SpecificityClone DE-U-10 is a mouse monoclonal antibody that detects Desmin. It targets an epitope within 48 amino acids from the C-terminal half of the protein.
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      • Rat
      • Hamster
      • Human
      Species Reactivity NoteHuman, Hamster, Mouse, Rat. Predicted to react with Porcine based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • DES
      Purification MethodProtein G purified
      UniProt Number
      Molecular WeightTarget molecular weight ~56 kDa observed. 59.63 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse skeletal muscle tissue lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected Desmin in mouse skeletal muscle tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsRecommended storage: +2°C to +8°C.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABT1565-100UG 04065271270206