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AP1035 Anti-Cyclophilin D Mouse mAb (E11AE12BD4)

This Anti-Cyclophilin D Mouse mAb (E11AE12BD4) is validated for use in Immunoblotting, Immunocytochemistry for the detection of Cyclophilin D.

Anti-Cyclophilin D Mouse mAb (E11AE12BD4): SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: Anti-CyPD

AP1035
  
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      Übersicht

      Replacement Information

      Key Spec Table

      Species ReactivityHostAntibody Type
      B, H, M, RMMonoclonal Antibody
      Description
      Overview

      This product has been discontinued.



      Recognizes the ~17-18 kDa processed form of mitochondrial cyclophilin D in cultured fibroblasts.
      Catalogue NumberAP1035
      Brand Family Calbiochem®
      SynonymsAnti-CyPD
      Application Data
      Detection of human cyclophilin D by immunoblotting. Sample: Heart mitochondria. Primary antibody: Anti-Cyclophilin D Mouse mAb (E11AE12BD4) (Cat. No. AP1035) (1 μg/ml). Detection: chemiluminescence.

      Detection of human cyclophilin D by immunocytochemistry. Sample: Cultured fibroblasts. Primary antibody: Anti-Cyclophilin D Mouse mAb (E11AE12BD4) (Cat. No. AP1035) (5 μg/ml). Detection: fluorescence.
      References
      ReferencesHalestrap, A.P., et al. 2003. Curr. Med. Chem. 10, 1507.
      Product Information
      FormLiquid
      FormulationIn HBS.
      Positive controlHeart mitochondria
      Preservative≤0.1% sodium azide
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Immunocytochemistry
      Application NotesImmunoblotting (1 µg/ml)
      Immunocytochemistry (5 µg/ml)
      Application CommentsUseful for detection of apoptosis related proteins. Antibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogenrecombinant, rat cyclophilin D
      ImmunogenRat
      CloneE11AE12BD4
      HostMouse
      IsotypeIgG₁
      Species Reactivity
      • Bovine
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      AP1035 0

      Documentation

      Anti-Cyclophilin D Mouse mAb (E11AE12BD4) SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Anti-Cyclophilin D Mouse mAb (E11AE12BD4) Analysenzertifikate

      TitelChargennummer
      AP1035

      Literatur

      Übersicht
      Halestrap, A.P., et al. 2003. Curr. Med. Chem. 10, 1507.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-February-2010 JSW
      SynonymsAnti-CyPD
      ApplicationImmunoblotting (1 µg/ml)
      Immunocytochemistry (5 µg/ml)
      Application Data
      Detection of human cyclophilin D by immunoblotting. Sample: Heart mitochondria. Primary antibody: Anti-Cyclophilin D Mouse mAb (E11AE12BD4) (Cat. No. AP1035) (1 μg/ml). Detection: chemiluminescence.

      Detection of human cyclophilin D by immunocytochemistry. Sample: Cultured fibroblasts. Primary antibody: Anti-Cyclophilin D Mouse mAb (E11AE12BD4) (Cat. No. AP1035) (5 μg/ml). Detection: fluorescence.
      DescriptionMouse monoclonal antibody purified by ammonium sulfate precipitation. Recognizes the ~17-18 kDa processed form of mitochondrial cyclophilin D (CyPD) protein.
      BackgroundCyclophilin D is a member of the immunophilin family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents, cyclosporin A (CsA) or FK506. Proteins that bind CsA are called cyclophilins. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPlase) whose activity is inhibited by the respective immunosuppressant compounds. Immunophilins accelerate folding of proteins in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline-containing proteins. Cyclophilin D is located in the intermembrane space of the mitochondria where it is an integral member of the permeability transition pore complex that includes the voltage dependent anion channel (VDAC) and adenine nucleotide translocase (ANT).
      HostMouse
      Immunogen speciesRat
      Immunogenrecombinant, rat cyclophilin D
      CloneE11AE12BD4
      IsotypeIgG₁
      Speciesbovine, human, mouse, rat
      Positive controlHeart mitochondria
      FormLiquid
      FormulationIn HBS.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative≤0.1% sodium azide
      CommentsUseful for detection of apoptosis related proteins. Antibody should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesHalestrap, A.P., et al. 2003. Curr. Med. Chem. 10, 1507.