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16-228 Anti-Cortactin (p80/85) Antibody, clone 4F11, Alexa Fluor® 488

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16-228
100 µg  
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      Übersicht

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Av, B, H, Ht, M, RFC, IF, WB, ICCMAlexaFluor®488Monoclonal Antibody
      Description
      Catalogue Number16-228
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Cortactin (p80/85) Antibody, clone 4F11, Alexa Fluor® 488
      Product Information
      FormatAlexaFluor®488
      Quality LevelMQ100
      Applications
      ApplicationDetect Cortactin (p80/85) using this Anti-Cortactin (p80/85) Antibody, clone 4F11, Alexa Fluor 488 validated for use in FC, IF, WB & IC.
      Key Applications
      • Flow Cytometry
      • Immunofluorescence
      • Western Blotting
      • Immunocytochemistry
      Biological Information
      ImmunogenMixture of affinity-purified tyrosine phosphoproteins from chick embryo fibroblasts expressing activated pp60src
      Cloneclone 4F11
      HostMouse
      SpecificityRecognizes Cortactin in rodent and human cells
      IsotypeIgG1
      Species Reactivity
      • Avian
      • Bovine
      • Human
      • Hamster
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.
      Gene Symbol
      • CTTN
      • EMS1
      • Amplaxin
      • 1110020L01Rik
      • FLJ34459
      Modifications
      • Phosphorylation
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q14247 # May contribute to the organization of cell structure. The SH3 motif may function as a binding region to cytoskeleton. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.
      SIZE: 550 amino acids; 61636 Da
      SUBUNIT: Interacts with SHANK2 and SHANK3 via its SH2 domain. Also interacts with FGD1 (By similarity). Interacts with PLXDC2.
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, ruffle (By similarity). Note=Associated with membrane ruffles and lamellipodia (By similarity).
      SIMILARITY: SwissProt: Q14247 ## Contains 7 cortactin repeats. & Contains 1 SH3 domain.
      Molecular WeightMr 80kDa and in avian cells, Mr 80kDa and 85kDa.
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
      Storage and Shipping Information
      Storage Conditions1 year at 4°C from date of shipment
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Bestellnummer GTIN
      16-228 04053252284731