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AM46 Anti-Caspase-8 (Ab-3) Mouse mAb (1-3)

Anti-Caspase-8, mouse mAb, clone 1-3, recognizes ~55-58 kDa latent form in non-apoptotic Jurkat cells & ~18 kDa active form in apoptotic Jurkat & HeLa cells. It is validated for Western blotti

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Anti-Caspase-8 (Ab-3) Mouse mAb (1-3): SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: Anti-ICE-LAP5, Anti-MACH, Anti-FLICE, Anti-CAP4, Anti-CASP8, Anti-Mch5

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      Übersicht

      Key Spec Table

      Species ReactivityHostAntibody Type
      HMMonoclonal Antibody
      Description
      Overview

      This product has been discontinued.



      Recognizes the ~55-58 kDa latent form of caspase-8 in non-apoptotic Jurkat cells and with ~18 kDa active form in apoptotic Jurkat or HeLa cells. Additional proteins at ~42-44 kDa corresponding to the heavier processed chain may appear in some apoptotic cell lines.
      Catalogue NumberAM46
      Brand Family Calbiochem®
      SynonymsAnti-ICE-LAP5, Anti-MACH, Anti-FLICE, Anti-CAP4, Anti-CASP8, Anti-Mch5
      References
      ReferencesSmyth, L.A. and Brady, H.J.M. 2005. Hypertension 46, 100.
      Fearnhead, H.O., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13664.
      Juo, P., et al. 1998. Curr. Biol. 8, 1001.
      Martin, D.A., et al. 1998. J. Biol. Chem. 273, 4345.
      Peter, M.E. and Krammer, P.H. 1998. Curr. Opin. Immunol. 10, 545.
      Sakamaki, K., et al. 1998. Eur. J. Biochem. 253, 399.
      Stennicke, H.R., et al. 1998. J. Biol. Chem. 273, 27084.
      Scaffifi, C., et al. 1997. J. Biol. Chem. 272, 26953.
      Stennicke, H.R. and Salvesen, G.S. 1997. J. Biol. Chem. 272, 25719.
      Muzio, M., et al. 1996. Cell 85, 817.
      Kischkel, F.C., et al. 1995. EMBO J. 14, 5579.
      Product Information
      FormLiquid
      FormulationIn 0.05 M sodium phosphate buffer, 0.2% gelatin.
      Negative controlAnti-trpE (Ab-1) Mouse mAb (I22-25) (Cat. No. OB01)
      Positive controlHeLa or Jurkat cells
      Preservative≤0.1% sodium azide
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Not Frozen Sections
      Not Immunofluorescence
      Not Immunoprecipitation
      Not Paraffin Sections
      Application NotesImmunoblotting (1 µg/ml)
      Frozen Sections (not recommended)
      Immunofluorescence (not recommended)
      Immunoprecipitation (not recommended)
      Paraffin Sections (not recommended)
      Application CommentsAdditional bands at ~42-44 kDa corresponding to the heavier processed chain may appear in some apoptotic cell lines. Antibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogenhuman recombinant caspase-8
      ImmunogenHuman
      Clone1-3
      HostMouse
      IsotypeIgG₁
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Concentration Label Please refer to vial label for lot-specific concentration
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Yes
      Global Trade Item Number
      Bestellnummer GTIN
      AM46 0