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ABC1484 Anti-Bcl-B Antibody

This Anti-Bcl-B Antibody is validated for use in Western Blotting_x000D_ and Immunocytochemistry for the detection of Bcl-B.

Anti-Bcl-B Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: BCL2L10, BCLB UniProt Number: Q9HD36
ABC1484
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC1484
      DescriptionAnti-Bcl-B Antibody
      Alternate Names
      • Bcl-2-like protein 10
      • Bcl2-L-10
      • Anti-apoptotic protein NrH
      • Apoptosis regulator Bcl-B
      • Bcl-B
      Background InformationThe protein named Bcl-2-like protein 10 (Bcl2-L-10) or alternatively Anti-apoptotic protein NrH or Apoptosis regulator Bcl-B, and encoded by the human gene BCL2L10/BCLB is member of the BcL2 anti-apoptosis family and promotes cell survival by suppressing the actions of BAX and BAK in destabilizing the mitochondrial membrane potential leading to apoptosis activation. Bcl-B can interact with Bcl-2, BcL2L1/BCL-XL, and BAX. It is expressed in the cytoplasm and interacts primarily at the mitochondrial membranes. Bcl-B is abundantly expressed in human embryos prior to implantation and was predominantly cytoplasmic with localization at the mitochondria in normal embryos. In abnormal embryos Bcl-B was outside the mitochondria as well as nuclear located, but the exact nature of the role of Bcl-B in abnormal embryos is still be elucidated. Interestingly, Bcl-B because of its anti-apoptotic effects is also the cause for anti-cancer drug resistance and it is used a marker for potential drug failures in anti-cancer therapy.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.02% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationThis Anti-Bcl-B Antibody is validated for use in Western Blotting_x000D_ and Immunocytochemistry for the detection of Bcl-B.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis (ICC): 10 μg/mL from a representative lot detected Bcl-B in Jurkat cells.
      Biological Information
      ImmunogenBcl-B antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human Bcl-B.
      EpitopeNear N-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • BCL2L10
      • BCLB
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~40 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Jurkat cell lysate.

      Western Blotting Analysis (WB): 1 μg/mL of this antibody detected Bcl-B in Jurkat cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABC1484 04055977174618