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ABN1481 Anti-Alpha 2b Adrenergic Receptor

Anti-Alpha 2b Adrenergic Receptor, Cat. No. ABN1481, is a highly specific rabbit polyclonal antibody that targets Alpha-2B adrenergic receptor and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-Alpha 2b Adrenergic Receptor: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Neuroscience Gene Symbol: ADRA2B, ADRA2L1, ADRA2RL1 UniProt Number: P18089
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ABN1481
100 μg  
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      Übersicht

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P), WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN1481
      DescriptionAnti-Alpha 2b Adrenergic Receptor
      Alternate Names
      • Alpha-2B adrenergic receptor
      • Alpha-2 adrenergic receptor subtype C2
      • Alpha-2B adrenoreceptor
      • Alpha-2B adrenoceptor
      • Alpha-2BAR Alpha-2 adrenergic receptor subtype C2
      • Alpha-2B adrenoreceptor
      • Alpha-2B adrenoceptor
      • Alpha-2BAR
      Background InformationAlpha-2B adrenergic receptor (UniProt: P18089; also known as Alpha-2 adrenergic receptor subtype C2, Alpha-2B adrenoreceptor, Alpha-2B adrenoceptor, Alpha-2BAR) is encoded by the ADRA2B (also known as ADRA2L1, ADRA2RL1) gene (Gene ID: 151) in human. Alpha-2-adrenergic receptors mediate part of the diverse biological effects of the endogenous catecholamines epinephrine and norepinephrine. Three subtypes of alpha-2-adrenergic receptors, 2A, 2B, and 2C, have been identified in multiple species. Alpha-2B adrenoreceptor is a heptahelical membrane protein of the G-protein coupled receptor 1 family. The extracellular regions of transmembrane (TM) segments 3, 5, and 6 are believed to be involved in ligand binding and intracellular ends of TM3 and TM6 participate in G-protein coupling. A deletion variant of the ADRA2B gene has been linked to the emotional enhancement of memory. This deletion variant is associated with greater extracellular nor-epinephrine availability and it predicts greater capacity for emotionally enhanced memory and increased tendency for intrusive traumatic memory. Mutations in ADRA2B gene have been linked to familial adult myoclonic epilepsy that is characterized by cortical myoclonus and variable occurrence of epileptic seizures.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Alpha 2b Adrenergic Receptor, Cat. No. ABN1481, is a highly specific rabbit polyclonal antibody that targets Alpha-2B adrenergic receptor and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A 1:250-1:1,000 dilution from a representative lot detected Alpha 2b Adrenergic Receptor in human cerebellum, human cerebral cortex, rat cerebellum, and rat hippocampus tissues.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to 14 amino acids from the internal region of human alpha-2B adrenergic receptor.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis polyclonal antibody detects alpha-2B adrenergic receptor in MCF-10A cells. It targets an epitope within 14 amino acids from the internal region.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ADRA2B
      • ADRA2L1
      • ADRA2RL1
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight~52 kDa observed; 49.57 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in MCF-10A cell lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected Alpha 2b Adrenergic Receptor in 10 µg of MCF-10A cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABN1481 04054839199004