124012 Sigma-AldrichAkt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem
Akt Inhibitor V, Triciribine, CAS 35943-35-2, is a cell-permeable, selective, reversible inhibitor of the cellular phosphorylation/activation of Akt1/2/3.
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Synonyme: NSC 154020, TCN, Akt/PKB Signaling Inhibitor-2, API-2
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 35943-35-2 | C₁₃H₁₆N₆O₄ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 124012-10MG |
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Glasflasche | 10 mg |
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| 124012-1MG |
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Kst.-Ampulle | 1 mg |
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| Description | |
|---|---|
| Overview | A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3. It does not inhibit known upstream activators of Akt, i.e. PI3K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥ 60% in cell proliferation at 20 µM) and in vivo (≥ 80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.). Also available in InSolution™ format (Cat. No. 124038). |
| Catalogue Number | 124012 |
| Brand Family | Calbiochem® |
| Synonyms | NSC 154020, TCN, Akt/PKB Signaling Inhibitor-2, API-2 |
| References | |
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| References | Karst, A., et al. 2006. Cancer Res. 66, 9225. Yang, L., et al. 2004. Cancer Res. 64, 4394. |
| Product Information | |
|---|---|
| CAS number | 35943-35-2 |
| ATP Competitive | N |
| Form | Solid |
| Hill Formula | C₁₃H₁₆N₆O₄ |
| Chemical formula | C₁₃H₁₆N₆O₄ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
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| Application | Akt Inhibitor V, Triciribine, CAS 35943-35-2, is a cell-permeable, selective, reversible inhibitor of the cellular phosphorylation/activation of Akt1/2/3. |
| Biological Information | |
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| Primary Target | Akt1, Akt 2, Akt3 |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS | |
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| RTECS | RY8455000 |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 124012-10MG | 04055977205640 |
| 124012-1MG | 04055977205633 |
Documentation
Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem SDB
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Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 124012 |
Literatur
| Übersicht |
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| Karst, A., et al. 2006. Cancer Res. 66, 9225. Yang, L., et al. 2004. Cancer Res. 64, 4394. |
Broschüre
| Titel |
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| Akt |
| Biologics 31.1 |