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116818 Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Bromo-, Sp-Isomer, Sodium Salt - Calbiochem

A potent cell-permeable, metabolically-stable activator of cAMP-dependent protein kinase (PKA).

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Synonyme: Sp-8-Br-cAMPS, Na

Primary Target: PKA
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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₀H₁₀BrN₅O₅PS · Na
      Description
      Overview

      This product has been discontinued.



      A potent cell-permeable, metabolically-stable activator of cAMP-dependent protein kinase (PKA). Induces guanine nucleotide exchange factor activity of GEFI (also known as Epac) and GEFII towards Rap1 both in vivo and in vitro. Significantly more lipophilic and cell-permeable than Sp-cAMPS (Cat. No. 116815). Note: 5 µmol = 2.23 mg.
      Catalogue Number116818
      Brand Family Calbiochem®
      SynonymsSp-8-Br-cAMPS, Na
      References
      ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
      de Rooij, J., et al. 1998. Nature 396, 474.
      Holen, I., et al. 1996. Eur. J. Biochem. 236, 163.
      Schaap, P., et al. 1993. J. Biol. Chem. 268, 6323.
      Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.
      Product Information
      ATP CompetitiveN
      DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
      FormLyophilized
      Hill FormulaC₁₀H₁₀BrN₅O₅PS · Na
      Chemical formulaC₁₀H₁₀BrN₅O₅PS · Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKA
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      116818 0

      Documentation

      Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Bromo-, Sp-Isomer, Sodium Salt - Calbiochem Analysenzertifikate

      TitelChargennummer
      116818

      Literatur

      Übersicht
      Kawasaki, H., et al. 1998. Science 282, 2275.
      de Rooij, J., et al. 1998. Nature 396, 474.
      Holen, I., et al. 1996. Eur. J. Biochem. 236, 163.
      Schaap, P., et al. 1993. J. Biol. Chem. 268, 6323.
      Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-September-2007 RFH
      SynonymsSp-8-Br-cAMPS, Na
      DescriptionA potent cell-permeable, metabolically stable activator of cAMP-dependent protein kinase (PKA). Induces the guanine-nucleotide-exchange factor activity of GEFI, also known as Epac (exchange protein directly activated by cAMP), and GEFII towards Rap1 both in vivo and in vitro. Significantly more lipophilic and cell permeable than Sp-cAMPS (Cat. No. 116815). λmax = 264 nm (H2O, pH 7.0); εmax = 17,000 M-1cm-1. Note: 5 µmol = 2.23 mg.
      FormLyophilized
      Chemical formulaC₁₀H₁₀BrN₅O₅PS · Na
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityH₂O (40 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
      de Rooij, J., et al. 1998. Nature 396, 474.
      Holen, I., et al. 1996. Eur. J. Biochem. 236, 163.
      Schaap, P., et al. 1993. J. Biol. Chem. 268, 6323.
      Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.