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116825 Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 2ʹ-O-Monobutyryl-, Rp-Isomer, Sodium Salt

A cell-permeable, metabolically-stable precursor of Rp-cAMPS that acts as a competitive inhibitor of protein kinase A type I and II.

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Synonyme: Rp-MB-cAMPS, Na, PKA Inhibitor X

Primary Target: PKA1, PKA2
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      152218-23-0C₁₄H₁₇N₅O₆PS · Na
      Description
      Overview

      This product has been discontinued.





      A cell-permeable, metabolically-stable precursor of Rp-cAMPS (Cat. No. 116814) that acts as a competitive inhibitor of protein kinase A type I and II. During metabolic activation by esterases, the inhibitor and butyrate are released. Reported to inhibit glucose-induced proliferation of the pancreatic β-cell line, INS-1. More lipophilic and cell-permeable than Rp-cAMPS.
      Note: 5 µmol = 2.19 mg.
      Catalogue Number116825
      Brand Family Calbiochem®
      SynonymsRp-MB-cAMPS, Na, PKA Inhibitor X
      References
      ReferencesVischer, U.M., and Wollheim, C.B. 1998. Blood 91, 118.
      Product Information
      CAS number152218-23-0
      ATP CompetitiveY
      DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
      FormLyophilized
      Hill FormulaC₁₄H₁₇N₅O₆PS · Na
      Chemical formulaC₁₄H₁₇N₅O₆PS · Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetPKA1, PKA2
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      116825 0

      Documentation

      Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 2ʹ-O-Monobutyryl-, Rp-Isomer, Sodium Salt Analysenzertifikate

      TitelChargennummer
      116825

      Literatur

      Übersicht
      Vischer, U.M., and Wollheim, C.B. 1998. Blood 91, 118.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-September-2007 RFH
      SynonymsRp-MB-cAMPS, Na, PKA Inhibitor X
      DescriptionA cell-permeable precursor of Rp-cAMPS (Cat. No. 116814), a PKA inhibitor. Rp-MB-cAMPS is cleaved by intracellular esterases to release butyrate and Rp-cAMPS. The Rp-cAMPS binds to the cAMP binding site on PKA type I and type II, thereby prevents holoenzyme dissociation and PKA activation. Has been shown to inhibit glucose-induced proliferation of the pancreatic β-cell line, INS-1. Note: 5 µmol = 2.19 mg.
      FormLyophilized
      CAS number152218-23-0
      Chemical formulaC₁₄H₁₇N₅O₆PS · Na
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesVischer, U.M., and Wollheim, C.B. 1998. Blood 91, 118.