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171263 AMPK Signaling Activator IX, F17 - CAS 280112-24-5 - Calbiochem

The AMPK Signaling Agonist, F17, also referenced under CAS 280112-24-5, controls the biological activity of AMPK. This AMPK activator and small molecule/inhibitor is primarily used for Biochemicals applications.

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Synonyme: 4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      280112-24-5C₁₈H₁₉N₃O₃S
      Description
      Overview

      This product has been discontinued.



      A cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~ 0.1 µM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-α1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25 µM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C (Cat. No. 171260).
      Catalogue Number171263
      Brand Family Calbiochem®
      Synonyms4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
      Application Data
      References
      ReferencesLemieux, G.A., et al. 2011. Nat. Chem. Biol. 7, 206.
      Product Information
      CAS number280112-24-5
      FormOff-white solid
      Hill FormulaC₁₈H₁₉N₃O₃S
      Chemical formulaC₁₈H₁₉N₃O₃S
      Quality LevelMQ100
      Applications
      ApplicationThe AMPK Signaling Agonist, F17, also referenced under CAS 280112-24-5, controls the biological activity of AMPK. This AMPK activator and small molecule/inhibitor is primarily used for Biochemicals applications.
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      171263 0

      Documentation

      AMPK Signaling Activator IX, F17 - CAS 280112-24-5 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      AMPK Signaling Activator IX, F17 - CAS 280112-24-5 - Calbiochem Analysenzertifikate

      TitelChargennummer
      171263

      Literatur

      Übersicht
      Lemieux, G.A., et al. 2011. Nat. Chem. Biol. 7, 206.

      Broschüre

      Titel
      New Products: Volume 3, 2012
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-April-2012 JSW
      Synonyms4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
      Application Data
      DescriptionA cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~ 0.1 µM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-α1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25 µM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C (Cat. No. 171260).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number280112-24-5
      Chemical formulaC₁₈H₁₉N₃O₃S
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml; clear, colorless solution). Warming to 55-60°C is required for complete solubilization.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLemieux, G.A., et al. 2011. Nat. Chem. Biol. 7, 206.