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658400 AG 82 - CAS 118409-58-8 - Calbiochem

A cell-permeable, reversible, and competitive inhibitor of substrate binding on protein tyrosine kinases.

AG 82 - CAS 118409-58-8 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: α-Cyano-(3,4,5-trihydroxy)cinnamonitrile, Tyrphostin A25

Primary Target: epidermal growth factor receptor tyrosine kinase
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      118409-58-8C₁₀H₆N₂O₃
      Description
      Overview

      This product has been discontinued.



      A cell-permeable, reversible, and competitive inhibitor of substrate binding on protein tyrosine kinases. Inhibits epidermal growth factor receptor tyrosine kinase (IC50 = 3 µM) and the GTPase activity of transducin (IC50 = 7 µM). Inhibits neuromedin B-induced phosphorylation of p125FAK (focal adhesion kinase). Blocks the induction of inducible nitric oxide synthase in glial cells. Induces apoptosis in human leukemic cell lines.
      Catalogue Number658400
      Brand Family Calbiochem®
      Synonymsα-Cyano-(3,4,5-trihydroxy)cinnamonitrile, Tyrphostin A25
      References
      ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
      Tsuda, T., et al. 1997. Biochemistry 36, 16328.
      Wolbring, G., et al. 1994. J. Biol. Chem. 269, 22470.
      Bergamaschi, G., et al. 1993. Leukemia 7, 2012.
      Piontek, M., et al. 1993. Anticancer Res. 13, 2119.
      Bilder, G.E., et al. 1991. Am. J. Physiol. 260, C721.
      Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
      Yaish, P., et al. 1988. Science 242, 933.
      Product Information
      CAS number118409-58-8
      ATP CompetitiveY
      FormDark yellow solid
      Hill FormulaC₁₀H₆N₂O₃
      Chemical formulaC₁₀H₆N₂O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetepidermal growth factor receptor tyrosine kinase
      Primary Target IC<sub>50</sub>3 µM against epidermal growth factor receptor tyrosine kinase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      658400 0

      Documentation

      AG 82 - CAS 118409-58-8 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      AG 82 - CAS 118409-58-8 - Calbiochem Analysenzertifikate

      TitelChargennummer
      658400

      Literatur

      Übersicht
      Jaleel, M., et al. 2004. Biochemistry 43, 8247.
      Tsuda, T., et al. 1997. Biochemistry 36, 16328.
      Wolbring, G., et al. 1994. J. Biol. Chem. 269, 22470.
      Bergamaschi, G., et al. 1993. Leukemia 7, 2012.
      Piontek, M., et al. 1993. Anticancer Res. 13, 2119.
      Bilder, G.E., et al. 1991. Am. J. Physiol. 260, C721.
      Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
      Yaish, P., et al. 1988. Science 242, 933.

      Broschüre

      Titel
      Caspases and other Apoptosis Related Tools Brochure
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-January-2010 RFH
      Synonymsα-Cyano-(3,4,5-trihydroxy)cinnamonitrile, Tyrphostin A25
      DescriptionA cell-permeable, reversible, and competitive inhibitor of substrate binding on protein tyrosine kinases. Inhibits epidermal growth factor receptor tyrosine kinase (IC50 = 3 µM) and the GTPase activity of transducin (IC50 = 7 µM). Blocks the induction of inducible nitric oxide synthase in glial cells. Induces apoptosis in human leukemic cell lines. Also reported to inhibit guanylyl cyclase.
      FormDark yellow solid
      CAS number118409-58-8
      Chemical formulaC₁₀H₆N₂O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml) or Methanol (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
      Tsuda, T., et al. 1997. Biochemistry 36, 16328.
      Wolbring, G., et al. 1994. J. Biol. Chem. 269, 22470.
      Bergamaschi, G., et al. 1993. Leukemia 7, 2012.
      Piontek, M., et al. 1993. Anticancer Res. 13, 2119.
      Bilder, G.E., et al. 1991. Am. J. Physiol. 260, C721.
      Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
      Yaish, P., et al. 1988. Science 242, 933.