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658404 AG 555

AG 555: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: α-Cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamide, Tyrphostin B46

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      Übersicht

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      Please refer to our complete listing of receptor tyrosine kinase inhibitors for possible alternatives. Please read all alternative product documentation carefully and contact technical service if you need additional information.





      A potent inhibitor of epidermal growth factor (EGF) receptor kinase autophosphorylation (IC50 = 700 nM). Exhibits opposite potency profiles with AG 527 (Cat. No. 658402) for EGF receptor autophosphorylation versus poly-GAT substrate phosphorylation.
      Catalogue Number658404
      Brand Family Calbiochem®
      Synonymsα-Cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamide, Tyrphostin B46
      References
      ReferencesRovin, B.H., and Tan, L.C. 1994. Kidney Int. 46, 1059. Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.
      Product Information
      FormYellow solid
      Hill FormulaC₁₉H₁₈N₂O₃
      Chemical formulaC₁₉H₁₈N₂O₃
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Targetepidermal growth factor (EGF) receptor kinase autophosphorylation
      Primary Target IC<sub>50</sub>700 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      658404 0

      Documentation

      AG 555 Analysenzertifikate

      TitelChargennummer
      658404

      Literatur

      Übersicht
      Rovin, B.H., and Tan, L.C. 1994. Kidney Int. 46, 1059. Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-September-2008 RFH
      Synonymsα-Cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamide, Tyrphostin B46
      DescriptionA potent inhibitor of epidermal growth factor (EGF) receptor kinase autophosphorylation (IC50 = 700 nM). Exhibits opposite potency profiles with Tyrphostin B44(-) (Cat. No. 658402) for EGF receptor autophosphorylation versus poly-GAT substrate phosphorylation.
      FormYellow solid
      Chemical formulaC₁₉H₁₈N₂O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO or ethanol (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesRovin, B.H., and Tan, L.C. 1994. Kidney Int. 46, 1059. Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.