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658402 AG 527

AG 527: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: (-)-(R)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidinecyanoacetamide, α-Cyano-(-)-(R)-N-(α-phenethyl)-3,4-dihydroxycinnamide, Tyrphostin B44(-)

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      Übersicht

      Replacement Information
      Description
      OverviewA cell-permeable, reversible, and substrate competitive inhibitor of epidermal growth factor (EGF) receptor kinase autophosphorylation (IC50 = 2.5 µM). Also inhibits phosphorylation of poly-GAT by the EGF receptor (IC50 = 400 nM).
      Catalogue Number658402
      Brand Family Calbiochem®
      Synonyms(-)-(R)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidinecyanoacetamide, α-Cyano-(-)-(R)-N-(α-phenethyl)-3,4-dihydroxycinnamide, Tyrphostin B44(-)
      References
      ReferencesGazit, A., et al. 1991. J. Med. Chem. 34, 1896.
      Product Information
      CAS number133550-32-0
      FormYellow solid
      Hill FormulaC₁₈H₁₆N₂O₃
      Chemical formulaC₁₈H₁₆N₂O₃
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Targetepidermal growth factor (EGF) receptor kinase autophosphorylation
      Primary Target IC<sub>50</sub>2.5 µM
      Secondary targetphosphorylation of poly-GAT by the EGF receptor (IC₅₀ = 400 nM)
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      658402 0

      Documentation

      AG 527 Analysenzertifikate

      TitelChargennummer
      658402

      Literatur

      Übersicht
      Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-January-2010 RFH
      Synonyms(-)-(R)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidinecyanoacetamide, α-Cyano-(-)-(R)-N-(α-phenethyl)-3,4-dihydroxycinnamide, Tyrphostin B44(-)
      DescriptionA cell-permeable, reversible, and substrate competitive inhibitor of epidermal growth factor (EGF) receptor kinase autophosphorylation (IC50 = 2.5 µM). Also inhibits the phosphorylation of poly-GAT by the EGF receptor (IC50 = 400 nM).
      FormYellow solid
      CAS number133550-32-0
      Chemical formulaC₁₈H₁₆N₂O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesGazit, A., et al. 1991. J. Med. Chem. 34, 1896.