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114810 ADAMTS-5 Inhibitor - CAS 929634-33-3 - Calbiochem

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Synonyme: 5-((4-Chlorobenzylthio-3-trifluoromethyl-N-methyl-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one, Aggrecanase-2 Inhibitor

Primary Target: ADAMTS-5
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      929634-33-3C₁₆H₁₁ClF₃N₃OS₃
      Description
      Overview

      This product has been discontinued.



      A thioxothiazolidinone compound that possesses a Zn2+-chelating structural motif and acts as an ADAMTS-5 (aggrecanase-2) inhibitor (IC50 = 1.1 µM) with ~40-fold selectivity over ADAMTS-4 (aggrecanase-1).
      Catalogue Number114810
      Brand Family Calbiochem®
      Synonyms5-((4-Chlorobenzylthio-3-trifluoromethyl-N-methyl-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one, Aggrecanase-2 Inhibitor
      References
      ReferencesBursavich, M.G., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1185.
      Gilbert, A.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1189.
      Product Information
      CAS number929634-33-3
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₆H₁₁ClF₃N₃OS₃
      Chemical formulaC₁₆H₁₁ClF₃N₃OS₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetADAMTS-5
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22-36/37/38

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 36/37

      Wear suitable protective clothing and gloves.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      114810 0

      Documentation

      ADAMTS-5 Inhibitor - CAS 929634-33-3 - Calbiochem Analysenzertifikate

      TitelChargennummer
      114810

      Literatur

      Übersicht
      Bursavich, M.G., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1185.
      Gilbert, A.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1189.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2011 RFH
      Synonyms5-((4-Chlorobenzylthio-3-trifluoromethyl-N-methyl-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one, Aggrecanase-2 Inhibitor
      DescriptionA thioxothiazolidinone compound that possesses a Zn2+-chelating structural motif and acts as an ADAMTS-5 (aggrecanase-2) inhibitor (IC50 = 1.1 µM) with ~40-fold selectivity over ADAMTS-4 (aggrecanase-1).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number929634-33-3
      Chemical formulaC₁₆H₁₁ClF₃N₃OS₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesBursavich, M.G., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1185.
      Gilbert, A.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1189.