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402087 7BIO - CAS 916440-85-2 - Calbiochem

A cell-permeable 6-BIO structural isomer that acts as an ATP-competitive inhibitor of Flt3 and a caspase-independent, non-apoptotic cell death inducer.

7BIO - CAS 916440-85-2 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: (2ʹZ,3ʹE)-7-Bromoindirubin-3ʹ-oxime, Indirubin-3ʹ-monoxime, 7-Bromo, 7-Bromoindirubin-oxime

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      916440-85-2C₁₆H₁₀BrN₃O₂
      Description
      OverviewA cell-permeable 6-BIO (Cat. Nos. 361550 and 361552) structural isomer that acts as an ATP-competitive inhibitor of Flt3 (IC50 = 340 nM) and a caspase-independent, non-apoptotic cell death inducer (IC50 of cell survival ranges from 6.0 µM to 22.0 µM). Inhibition study against 75 other kinases reveals 10- to 80-fold selectivities over a group of 14 kinases, including TSF1, Aurora-A, and Aurora-B (IC50 = 3.3, 4.7, and 6.6 µM, respectively), up to 280-fold selectivities over a second group of 15 kinases, and little activity against the remaining 46 kinases of the panel (IC50 >100 µM).
      Catalogue Number402087
      Brand Family Calbiochem®
      Synonyms(2ʹZ,3ʹE)-7-Bromoindirubin-3ʹ-oxime, Indirubin-3ʹ-monoxime, 7-Bromo, 7-Bromoindirubin-oxime
      References
      ReferencesZahler, S., et al. 2007. Chem. Biol. 14, 1207.
      Myrianthopoulos, V., et al. 2007. J. Med. Chem. 50, 4027.
      Ferandin, Y., et al. 2006. J. Med. Chem. 49, 4638.
      Ribas, J., et al. 2006. Oncogene 25, 6304.
      Product Information
      CAS number916440-85-2
      FormDeep black-red solid
      Hill FormulaC₁₆H₁₀BrN₃O₂
      Chemical formulaC₁₆H₁₀BrN₃O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      402087 0

      Documentation

      7BIO - CAS 916440-85-2 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      7BIO - CAS 916440-85-2 - Calbiochem Analysenzertifikate

      TitelChargennummer
      402087

      Literatur

      Übersicht
      Zahler, S., et al. 2007. Chem. Biol. 14, 1207.
      Myrianthopoulos, V., et al. 2007. J. Med. Chem. 50, 4027.
      Ferandin, Y., et al. 2006. J. Med. Chem. 49, 4638.
      Ribas, J., et al. 2006. Oncogene 25, 6304.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-May-2011 RFH
      Synonyms(2ʹZ,3ʹE)-7-Bromoindirubin-3ʹ-oxime, Indirubin-3ʹ-monoxime, 7-Bromo, 7-Bromoindirubin-oxime
      DescriptionA cell-permeable 6-BIO (Cat. Nos. 361550 and 361552) structural isomer that acts as an ATP-competitive inhibitor of Flt3 (IC50 = 340 nM) and a caspase-independent, non-apoptotic cell death inducer (IC50 of cell survival ranges from 6.0 µM to 22.0 µM). Inhibition study against 75 other kinases reveals 10- to 80-fold selectivities over a group of 14 kinases, including TSF1, Aurora-A, and Aurora-B (IC50 = 3.3, 4.7, and 6.6 µM, respectively), up to 280-fold selectivities over a second group of 15 kinases, and little activity against the remaining 46 kinases of the panel (IC50 >100 µM).
      FormDeep black-red solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number916440-85-2
      Chemical formulaC₁₆H₁₀BrN₃O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Regulatory Review
      ReferencesZahler, S., et al. 2007. Chem. Biol. 14, 1207.
      Myrianthopoulos, V., et al. 2007. J. Med. Chem. 50, 4027.
      Ferandin, Y., et al. 2006. J. Med. Chem. 49, 4638.
      Ribas, J., et al. 2006. Oncogene 25, 6304.