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ECM410 α5β1 Integrin Investigator Kit

α5β1 Integrin Investigator Kit: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Cell Structure Research Sub-Category: Integrins Gene Symbol: ITGA5, VLA-5, CD49e, VLA5A, FNRA UniProt Number: P08648
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ECM410
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      Description
      Catalogue NumberECM410
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      Descriptionα5β1 Integrin Investigator Kit
      OverviewChemicon Investigator Kits for Integrin Research are a cost-effective source of reagents for investigators involved with this rapidly expanding field of study. The alpha5beta1 Investigator kit is designed for research focused specifically on the alpha5beta1 integrin.

      Integrins belong to a large family of cell surface proteins commonly referred to as glycoproteins. Integrins are composed of noncovalently associated alpha and beta subunits which make up heterodimers: the larger termed alpha chain and the smaller beta chain. At least 16 alpha subunits and 8 beta subunits are expressed, which can give rise to 22 different integrins. Integrins are thought to play critical roles in cell migration, differentiation, and survival. There is now considerable evidence that these transmembrane receptors play an important role in the regulation of gene expression and signal transduction. Excellent reviews of integrin structure, function, and ligand specificity may be found in: Hynes, R. 1992. Cell 69:11-25; Kramer, R. 1993. "Integrin Structure and Ligand Specificity in Cell-Matrix Interactions" in Molecular and Cellular Aspects of Basement Membranes. Academic Press.

      Chemicon offers the Integrin alpha5beta1 Investigator Kit for initial studies of alpha5beta1 interactions. All kit reagents are also available in larger sizes. The reagents in this kit are not application specific but rather may be used in a variety of procedures, depending upon the needs of the individual investigator.
      References
      Product Information
      Components
      • alpha5 Mouse Monoclonal Antibody (Part No. MAB1956Z-20) - 1 tube, 20 μg.
      • beta1 Mouse Monoclonal Antibody (Part No. MAB1951Z-20) - 1 tube, 20 μg.
      • alpha5beta1 Mouse Monoclonal Antibody (Part No. MAB1999-20) - 1 tube, 20 μg.
      • Purified alpha5beta1 Protein (Part No. CC1052-10) - 1 tube, 10 μg.
      PresentationChemicon's alpha5beta1 Integrin Investigator Kit provides researchers with an economical way of performing investigative research on the alpha5beta1 integrin. This kit provides 20 μg each of monoclonals to alpha5, beta1, alpha5beta1, and 10 μg of purified alpha5beta1 protein.
      Quality LevelMQ100
      Applications
      Key Applications
      • Immunohistochemistry
      • Immunocytochemistry
      • Western Blotting
      Biological Information
      Species Reactivity
      • Human
      Entrez Gene Number
      Entrez Gene SummaryThe product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
      Gene Symbol
      • ITGA5
      • VLA-5
      • CD49e
      • VLA5A
      • FNRA
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08648 # Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
      SIZE: 1049 amino acids; 114536 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5. Interacts with HIV-1 Tat.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P08648 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore antibodies at -20°C and the purified integrin protein at -70°C.

      Important Note: Due to the small volumes contained within the kit, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge before opening the vial to dislodge any liquid entrapped in the container's cap during shipment.
      Packaging Information
      Material Size1 kit
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ECM410 04053252020872